Isolation from Cannabis sativa L. of cannflavin--a novel inhibitor of prostaglandin production |
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| Authors: | M L Barrett D Gordon F J Evans |
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| Affiliation: | 2. Departamento de Química, FCEyN, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina;3. INTEMA-CONICET-Universidad Nacional de Mar del Plata, Mar del Plata, Argentina;4. IFIMAR-CONICET-Universidad Nacional de Mar del Plata, Mar del Plata, Argentina;1. Departamento de Química, Universidade Federal do Espírito Santo (UFES), Avenida Fernando Ferrari, 514, Goiabeiras, Vitória, ES CEP: 29075-910, Brazil;2. Instituto Nacional de Ciência e Tecnologia Forense (INCT Forense), Vila Velha, ES 29106-010, Brazil;3. Instituto Federal do Espírito Santo (IFES), Av. Ministro Salgado Filho, Soteco, Vila Velha, ES 29106-010, Brazil |
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| Abstract: | ![]()
The isolation from Cannabis sativa L. of an inhibitor of prostaglandin (PG) E2 production by cultured rheumatoid synovial cells is described. This agent, for which the name Cannflavin has been coined, is distinct from cannabinoids on the basis of isolation procedure, preliminary structural analysis and biological properties. The activity of Cannflavin has been compared with several established anti-inflammatory drugs and the major cannabinoids. |
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