| 益气温阳护卫法对哮喘大鼠IL-4/STAT6信号通路的影响 |
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| 引用本文： | 余建玮,薛汉荣,洪广祥,邱小华,邹叶青,程光宇,付向春,杨玉萍,兰智慧. 益气温阳护卫法对哮喘大鼠IL-4/STAT6信号通路的影响[J]. 中华中医药杂志, 2008, 23(12): 1082-1084 |
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| 作者姓名： | 余建玮 薛汉荣 洪广祥 邱小华 邹叶青 程光宇 付向春 杨玉萍 兰智慧 |
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| 作者单位： | [1]江西中医学院呼吸病研究所,南昌330006 [2]江西省分子医学研究中心,南昌330006 |
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| 基金项目： | 国家自然科学基金资助项目，江西省自然科学基金 |
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| 摘 要： | 目的:探讨益气温阳护卫法对哮喘大鼠白细胞介素4/信号传导子及转录激活子6(IL-4/STAT6)信号通路的调节作用.方法:50只SPF级雄性SD大鼠随机分为正常对照组、哮喘模型组、益气温阳护卫组、地塞米松组和卡介菌多糖核酸组,每组10只.采用TaqMan Real time PcR测定哮喘大鼠Th细胞IL-4和STAT6的mRNA表达变化.结果:哮喘模型组IL-4和STAT6的mRNA表达显著高于正常对照组(P＜0.01),益气温阳护卫组、地塞米松组和卡介菌多糖核酸组PBMC中IL-4和STAT6的mRNA表达显著低于哮喘模型组(P＜0.01),且与正常对照组IL-4和STAT6的mRNA表达相当.结论:益气温阳护卫法能够抑制哮喘大鼠IL-4/STAT6信号通路基因的表达,该作用可能是调节Th1/Th2细胞亚群趋于平衡的重要机制.
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| 关 键 词： | 益气温阳护卫法 哮喘 |
Effect of Yiqiwenyanghuwei method on signal pathway of IL-4/STAT6 in asthma rats |
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| YU Jian-wei,XUE Han-rong,HONG Guang-xiang,QIU Xiao-hua,ZOU Ye-qing,CHENG Guang-yu,FU Xiang-chun,YANG Yu-ping,LAN Zhi-hui. Effect of Yiqiwenyanghuwei method on signal pathway of IL-4/STAT6 in asthma rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2008, 23(12): 1082-1084 |
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| Authors: | YU Jian-wei XUE Han-rong HONG Guang-xiang QIU Xiao-hua ZOU Ye-qing CHENG Guang-yu FU Xiang-chun YANG Yu-ping LAN Zhi-hui |
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| Affiliation: | YU Jian-wei1,XUE Han-rong1,HONG Guang-xiang1,QIU Xiao-hua2,ZOU Ye-qing2,CHENG Guang-yu1,FU Xiang-chun1,YANG Yu-ping1,LAN Zhi-hui1(1Institute of Respiratory Disease,Jiangxi College of TCM,Nanchang 330006,China,2Jiangxi Research Center of Moclecular Medicine,China) |
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| Abstract: | Objective:To explore the effect of Yiqiwenyanghuwei method on signal pathway of IL-4/STAT6 in asthma rats.Methods:Fifty SPF male SD rats were randomly divided into 5 groups:the normal control group,the asthma group,the Yiqiwenyanghuwei group,the Dexamethasone group,the BCG-PSN group.The mRNA expression of IL-4 and STAT6 in the PBMC of all groups were detected by TaqMan Real time PCR.Results:The mRNA expression of IL-4 and STAT6 in PBMC of asthma group was signi cantly higher than that of control group(P<0.0... |
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| Keywords: | IL-4 STAT6 |
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