血脂异常与结直肠瘤的关系

目的：探讨江苏南京地区人群血脂异常和结直肠瘤（ colorectal neoplasm ， CRN）发病风险的关系。方法收集并比较2012年6月-2013年11月67例结直肠癌（ colorectal cancer ，CRC）患者、34例结直肠腺瘤（ color-ectal adenoma ，CRA）患者和100例健康体检者的血脂检测结果。结果 CRN患者血清总胆固醇（ TC）和低密度脂蛋白胆固醇（LDL）水平较健康体检者显著增高（P＜0．05）。亚组分析发现CRA患者的血清TC和LDL水平明显高于健康体检者，脂蛋白a（Lip-a）水平明显低于健康体检者（P＜0．05）。结论 CRA而非CRC患者血清TC和LDL水平明显高于健康体检者，而CRN患者血清Lip-a水平明显低于健康体检者。

Association bet ween dyls ipidemia with colorectal neoplasm

Objective To investigate the relationship between dyslipidemia and colorectal neoplasm （ CRN ） in a case-control study among the population in Nanjing area .Methods The serum samples were collected from 67 colorectal cancer （ CRC） patients, 34 colorectal adenoma（ CRA） patients and 100 healthy subjects who were admitted into our hospital from June 2012 to November 2013 .Results The levels of serum total cholesterol （ TC） and low density lipopro-tein cholesterol （LDL） in patients with CRN were significantly increased than those of the healthy subjects （P〈0.05）. Subgroup analysis showed that the CRA patients produced remarkably higher amounts of serum TC and LDL , but lower quantities of Lip-a than the healthy subjects （P〈0.05）.Conclusion Patients with CRA, rather than CRC produce remarkably higher levels of serum TC and LDL than healthy subjects .In contrast, the amount of serum Lip-a was signif-icantly decreased in patients with CRN than the healthy subjects .