脂微球前列腺素E1治疗糖尿病性周围神经病变的临床研究

目的：观察脂微球前列腺素E1（Lipo PGE1）制剂对糖尿病性周围神经病变的治疗作用。方法：2型糖尿病（DM）合并糖尿病性周围神经病变患者42例，随机分为两组：治疗组（Lipo PGE1治疗）和对照组（维生素B1和维生素B12治疗），观察两组治疗前、后临床症状和神经电生理检查的改变。结果：经20天治疗后，治疗组患者肢体疼痛、麻木、感觉减退均有不同程度改善，神经电生理检查示感觉神经传导速度（SCV）、运动神经传导速度（MCV）增加，以上疗效均优于对照组。结论：Lipo PGE1能明显改善糖尿病性周围神经病变的临床症状和神经传导速度（NCV），对糖尿病性周围神经病变有治疗作用。以上疗效可能是通过PGE1的扩张血管和抑制血小板聚集的双重作用，改善微血管病变引起的神经供血和代谢异常。

Clinical research of Lipo PGE1 in the treatment of diabetic peripheral neuropathy

Objective: To observe the therapeutical effects of Lipo PGE_ 1 in the treatment of diabetic peripheral neuropathy. Methods: 42 cases of type 2 diabetes patients with diabetic peripheral neuropathy were recruited and were divided into two groups at random:therapy group treated with Lipo PGE_ l and control group treated with Vitamine B_ 1 and Vitamine B_ l2 . Results: After a treatment of 20 days,symptoms such as pain,numbness and hypoesthesia in cases of therapy group had been improved at different degrees.Examination of Neuroelectrophysiology indicated an increase of sensory nerves conduction velocity and motor nerve conduction velocity.The effects of therapy group outweighed that of control group. Conclusion: Lipo PGE_ 1 can significantly relief the symptoms of diabetic peripheral neuropathy and increase nerve conduction velocity.The mechanism of action may involve improvement of blood-supply of nerve by vasodilatation and inhibition of platelet aggregation that caused by PGE_ l .