| 不同剂量的人参水提液皮下注射对大鼠慢性绿脓杆菌性肺炎模型的影响 |
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| 引用本文： | 宋志军,JohansenHK,FaberV,MoserC,吴红,KharazmiA,HoibyN.不同剂量的人参水提液皮下注射对大鼠慢性绿脓杆菌性肺炎模型的影响[J].中国中西医结合杂志,1998(9):546-549. |
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| 作者姓名： | 宋志军 JohansenHK FaberV MoserC 吴红 KharazmiA HoibyN |
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| 摘 要： | 目的 :探讨人参水提液 (简称人参液 )对大鼠慢性绿脓杆菌 (PA)性肺炎模型的影响。方法 :采用 4种不同剂量的人参液皮下注射 ,观察用药两周后的疗效。结果 :4种剂量的人参液均可显著减少肺部大体观病变和肺脓肿率 (P <0 0 5) ;镜下观其病变程度与人参剂量呈负相关 (r=-0 95,P <0 0 1 ) ;人参Ⅰ (5mg/kg)、Ⅱ (2 5mg/kg)、Ⅳ (0 6 2 5mg/kg)组的肥大细胞数低于对照组 (P <0 0 5) ;Ⅱ、Ⅲ (1 2 5mg/kg)组的肺部细菌清除作用强于对照组 (P <0 0 5) ;Ⅱ、Ⅲ、Ⅳ组的PA特异性抗体应答发生下调 (P <0 0 1 ) ;Ⅰ组的IgM水平低于对照组(P <0 0 1 ) ,且IgM水平的高低与人参剂量呈正相关 (r =0 93,P <0 0 5) ;Ⅰ组的IgG2a水平高于对照组 (P <0 0 5) ;血清IgG2a水平与人参剂量呈正相关 (r =0 90 ,P <0 0 2 ) ;PA感染两周后 ,Ⅰ、Ⅱ、Ⅲ组的抗藻酸盐IgG水平高于对照组和Ⅳ组 (P <0 0 5) ,而Ⅰ、Ⅲ、Ⅳ组的IgA则低于对照组 (P <0 0 5)。结论 :2 5mg/kg的人参是本研究的最佳剂量 ,并显示了兴奋T辅助细胞Ⅰ型反应的效果
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| 关 键 词： | 人参水提液 绿脓杆菌 肺部感染 囊状纤维化 |
Effects of Subcutaneous Injection with Different Doses of Ginseng on the Rat Model of Chronic Pseudomonas Aeruginosa Pneumonia |
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| Institution: | Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark;Song Zhijun, Johansen HK, Faber V, et al Department of Clinical Microbiology and Department of Communicable and Tropical Diseases, The National University Hospital, Copenhagen, Denmark |
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| Abstract: | |
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| Keywords: | ginseng aqueous extract Pseudomonas aeruginosa lung infection cystic fibrosis |
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