骨髓间充质干细胞移植治疗脊髓损伤的研究现状

目的综述有关骨髓间充质干细胞（marrow mesenchymal stem cells,MSCs）移植治疗脊髓损伤（spinal cord injury,SCI）的新进展。方法广泛查阅近年来国内外相关文献,对MSCs生物学特性、移植治疗SCI的实验研究、移行机制、治疗机制和存在的问题进行讨论和分析。结果动物实验和临床研究表明,MSCs移植治疗SCI已有很大进展,移植治疗后,移植细胞能向损伤部位移行,并能分化为神经样细胞和分泌神经营养物质,具有促进损伤脊髓修复和神经功能恢复的作用,但也存在许多问题。结论MSCs移植治疗SCI是一种行之有效的方法,但仍有许多问题有待解决。

ADVANCES IN REPAIR OF SPINAL CORD INJURY BY TRANSPLANTATION OF MARROW MESENCHYMAL STEM CELLS

Objective To review the advances in repair of spinal cord injury by transplantation of marrow mesenchymal stem cells(MSCs).Methods The related articles in recent years were extensively reviewed,the biological characteristic of MSCs,the experimental and clinical studies on repair of spinal cord injury by transplantation of MSCs,the machanisms of immigration and therapy and the problems were discussed and analysed.Results The experimental and clinical studies demonstrated that the great advances was made in repair of spinal cord injury by transplantation of MSCs.After transplantation,MSCs could immigrate to the position of spinal cord injury,and differentiate into nerve-like cells and secrete neurotrophic factors.So it could promote repair of injuryed spinal cord and recovery of neurological function.Conclusion Transplantation of MSCs was one of effective ways in repair of spinal cord injury,but many problems remain to be resolved.