派丽奥软膏辅助治疗慢性牙周炎的疗效观察

目的:评价派丽奥牙科用软膏治疗慢性牙周炎的临床效果。方法:用随机、单盲、自身对照的方法,以单纯基础治疗为对照,评价将派丽奥牙周袋内用药辅助治疗牙周炎的疗效。记录基线、用药后1周、4周及8周的菌斑指数(PLI)、牙龈指数(GI)和牙周探诊深度(PD)。对数据进行统计学处理,对于PLI、GI两组均值间的比较用Wilcoxon秩和检验,而PD各均值的比较采用t检验。结果:实验组和对照组在基线时各临床指标无显著性差异(P>0.05)。经龈下刮治及根面平整术后1周,实验组与对照组较基线PLI、GI、PD均有显著改善(P<0.01);辅助用药后,实验组较对照组PLI在用药后1周有显著差异,其余各观察时段PLI无显著差异(P>0.05)。GI2组间在用药后1周无显著性差异(P>0.05),但用药后4周及8周有显著差异(P<0.05)。PD在用药后1、4及8周均有显著差异(P<0.05及P<0.01)。结论:牙周炎治疗以机械的洁、刮治为基础,派丽奥局部辅助用药能够提高牙周炎治疗的效果。

A clinical study of Periocline on the treatment of severe chronic periodontitis

PURPOSE:To evaluate the clinical effect of subgingivally administering Periocline as an auxiliary treatment of chronic periodontitis. METHODS: A randomized, single-blind, self-control study was designed.Following initial therapy ,Periocline was administered into the periodontal pocket of treatment sides at baseline and week 1 to week 4, but the control sides received no drug. For both groups,standard clinical indices including plaque index (PLI), gingival index(GI), probing depth (PD) and response to the ointments were evaluated at baseline week 1,week 4 and week 8. The plaque index and gingival index were analyzed by Wilcoxon' test for each treatment.The probing depth was analyzed by Student's t test. RESULTS: At the baseline,there was no significant difference in the indexes between the two groups(P>0.05). At 1 week after treatment , both groups showed significant improvement in their examined indexes(P<0.01).At week 1 the PLI was significantly lower in the experimental group than that in the control group;at week 4and week 8 there was no significant difference between the groups. At 1 week after the treatment, the GI had no significant difference between the two groups(P>0.05);but there was difference 4 weeks and 8 weeks after treatment. At 1 week after treatment,PD was significantly different between the two groups(P<0.05),while at week 4 and week 8 ,were significant difference between the two groups(P<0.01). CONCLUSION: Administration of the local drug delivery system of Periocline ointment as the auxiliary treatment of severe chronic Periodontitis could get good clinical results.