| 活血生津煎剂对免疫缺陷小鼠免疫功能的调节作用 |
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| 引用本文： | 华红,徐治鸿. 活血生津煎剂对免疫缺陷小鼠免疫功能的调节作用[J]. 中国中西医结合杂志, 2004, 0(Z1) |
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| 作者姓名： | 华红 徐治鸿 |
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| 作者单位： | 北京大学口腔医学院中医黏膜科 北京100081) |
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| 摘 要： | 目的观察活血生津煎剂对免疫缺陷小鼠免疫功能的影响。方法以免疫抑制剂环磷酰胺(Cy)处理 BALB/C 小鼠,而获得免疫缺陷小鼠模型。实验组受试药物为活血生津煎剂,设高剂量组、中剂量组和低剂量组,同时选六味地黄汤作为阳性对照药。结果与环磷酰胺组比较,活血生津煎剂高剂量组及阳性对照组小鼠胸腺指数增加,NK 细胞活性提高,动物血清溶血素抗体水平增加,TNF-αIL-2、IL-6 活性提高,差异有显著性(P<0.05)。结论活血生津煎剂多角度提高免疫低下小鼠的细胞和体液免疫功能。
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| 关 键 词： | 活血生津煎剂 免疫缺陷小鼠 免疫功能 调节 |
Regulatory Fumction of Huoxue Shengjin Decoctum on the Immune Function in Immunodeficiency Mice |
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| HUA Hong XU Zhi-hong ZHAO Nai-kun School of Stomatology,Peking University,Beijing. Regulatory Fumction of Huoxue Shengjin Decoctum on the Immune Function in Immunodeficiency Mice[J]. Chinese journal of integrated traditional and Western medicine, 2004, 0(Z1) |
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| Authors: | HUA Hong XU Zhi-hong ZHAO Nai-kun School of Stomatology Peking University Beijing |
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| Abstract: | Objective To observe the effect of Huoxue Shengjin Decoctum(HSD)on the immune function in immunodeficiency mice.Methods Mice were prepared with Cyclophosphamide(Cy),an immune-inhibitory agent,in such a way a model of immunodeficiency mice model was obtained.HSD of large,middle and small dosage were given to the mice in the experimen- tal group.Besides,Liuwei Dihuang Decoction was taken as the positive control.Results Compared with Cy,the thymus in- dex was increased,natural killer cell activity enhanced,serum hemolysin antibody level increased,activity of interleukin-2 and interleukin-6 enhanced between the large dosage of HSD and the positive control group with significant difference(P< 0.05).Conclusion HSD could enhance the cellular and humoural immunity of immunodeficiency mice by multi-way. |
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| Keywords: | Huoxue Shengjin Decoctum immunodeficiency mice immune function regulation |
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