|
|||||
|
|
| 高效凝胶渗透色谱法测定羟乙基淀粉相对分子质量的研究 | |
| 引用本文： | 陈蔚江,范慧红,徐康森. 高效凝胶渗透色谱法测定羟乙基淀粉相对分子质量的研究[J]. 中国药师, 2002, 5(9): 519-521 |
| 作者姓名： | 陈蔚江 范慧红 徐康森 |
| 作者单位： | 1. 湖北省药品检验所,武汉,430064 2. 中国药品生物制品检定所 |
| 摘 要： | 目的:研究不同标准品对高效凝胶渗透色谱法(HPGPC)测定羟乙基淀粉(HES)相对分子质量的影响。方法:分别采用葡聚糖和可溶性淀粉为标准品,以HPGPC法测定羟乙基淀粉相对分子量及其分布。结果:分别以两种标准品测定的HES200/0.5样品的重均相对分子量分别为113 259和 87 375,分布宽度分别为4.49和 2.35。结论:不同标准品对HPGPC测定羟乙基淀粉(HES)相对分子质量的影响较大。 |
| 关 键 词： | 色语法 高效凝胶渗透 羟乙基淀粉 分子质量 相对 |
| 文章编号： | 1008-049X(2002)09-0519-03 |
| 修稿时间： | 2002-04-20 |
Determination of the Relative Molecular Weight of HES by HPGPC |
|
| Chen Weijiang. Determination of the Relative Molecular Weight of HES by HPGPC[J]. China Pharmacist, 2002, 5(9): 519-521 | |
| Authors: | Chen Weijiang |
| Abstract: | Objective: To test the influence of different reference samples on HPGPC (High Performace Gel Permeation Chro-matography)to determine the relative molecular weight(RMW) of Hydroxyethyl Starch(HES). Method: Dextran an pullulan were used as reference standards respectively in determining the RMW of HES and its distribution of HES. Results; The RMW and its distribution of HES obtained by use of dextran were 113 259 and 4.49, respectively. Howerer, they were 87 375 and 2.35 respectively by use of pullulan. Conclusion:The calibration may have biger influences on determining RMW of HES by HPGPC. |
| Keywords: | HPGPC HES RMW |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中国药师》浏览原始摘要信息 | |
| 点击此处可从《中国药师》下载全文 | |