| 新诊断的2型糖尿病患者胰岛素强化治疗前后氧化应激水平的变化 |
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| 引用本文： | 黄海,祝开思,王平,张世俊.新诊断的2型糖尿病患者胰岛素强化治疗前后氧化应激水平的变化[J].中华糖尿病杂志,2011,19(5):338-339. |
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| 作者姓名： | 黄海 祝开思 王平 张世俊 |
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| 作者单位： | 黄海,祝开思,王平(中国人民解放军第305医院内分泌科,北京,100017);张世俊(全军老年病实验室中心) |
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| 摘 要： | 目的评价新诊断的2型糖尿病（T2DM）患者胰岛素强化治疗前后氧化应激水平的变化。方法30例新诊断的T2DM患者采用胰岛素泵强化治疗，治疗前后进行超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—Px）、丙二醛（MDA）水平测定。结果胰岛素泵强化治疗后，患者血浆中的SOD、GSH—Px水平明显上升（P〈0．01）、MDA水平明显下降（P〈0．01）。结论新诊断的T2DM患者胰岛素强化治疗后氧化应激水平明显降低。
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| 关 键 词： | 糖尿病 2型 胰岛素泵 氧化应激 |
The effect of continuous subcutaneous insulin infusion on oxidative stress level in newly diagnosed type 2 diabetic patients |
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| Institution: | HUANG Hai, ZHU Kai-si, WANG Ping, et al. Department of Endocrinology, PLA 305 Hospital, Beijing 100017, China |
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| Abstract: | Objective To evaluate the effect of continuous subcutaneous insulin infusion （CSII） on oxidative stress level in newly diagnosed T2DM patients. Methods 30 newly diagnosed T2DM patients were treated with continuous subcutaneous insulin infusion. The levels of SOD, GSH-Px and MDA were measured after insulin pump therapy. Results After the treatment, SOD and GSH-Px had more significant improvement. Otherwise, MDA was significantly＇ decreased （ P 〈 0. 01 ）. Conclusions Oxidative stress level of newly diagnosed T2DM patients is significantly decreased after continuous subcutaneous insulin infusion treatment. |
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| Keywords: | Diabetes mellitus type 2 Insulin pump Oxidative stress |
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