| 肺黏液表皮样癌的分子特征 |
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| 引用本文： | 庄武,王文娴,林雪平,黄韵坚,许春伟,陈燕坪,方美玉,朱有才,陆燕,陈刚. 肺黏液表皮样癌的分子特征[J]. 国际病理科学与临床杂志, 2017, 37(7). DOI: 10.3978/j.issn.2095-6959.2017.07.010 |
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| 作者姓名： | 庄武 王文娴 林雪平 黄韵坚 许春伟 陈燕坪 方美玉 朱有才 陆燕 陈刚 |
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| 作者单位： | 1. 福建医科大学附属福建省肿瘤医院胸部肿瘤内科,福州,350014;2. 浙江省肿瘤医院胸部肿瘤内科,杭州,310022;3. 浙江省荣军医院病理科,浙江 嘉兴,314000;4. 福建医科大学附属福建省肿瘤医院病理科,福州,350014;5. 浙江省肿瘤医院综合肿瘤内科,杭州,310022;6. 浙江省荣军医院胸部疾病诊疗中心,浙江 嘉兴,314000;7. 嘉兴市第二医院内科,浙江 嘉兴,314000 |
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| 基金项目： | 国家临床重点专科建设项目，福建省科技厅引导性项目，福建省科技厅引导性项目，浙江省卫生科研计划基金，浙江省中医药局科研基金，浙江省科技厅公益类科研计划，吴阶平医学基金会临床科研资金项目，嘉兴市科技计划项目，嘉兴市科技局项目(2014AY21031-6).This work was supported by National Clinical Key Specialty Construction Program，Leading Project Foundation of Science Department of Fujian Province，Leading Project Foundation of Science Department of Fujian Province，Medical Scientific Research Foundation of Zhejiang Province，Zhejiang Administration of Traditional Chinese Medicine Foundation，The Science and Technology Planning Project of Zhejiang Province，Wu Jieping Medical Foundation Clinical Scientiflc Research Project，Science and Technology Plan Projects of Jiaxing of Zhejiang，Scientiflc and Technologic Bureau Projects of Jiaxing of Zhejiang，China |
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| 摘 要： | 目的:探讨肺黏液表皮样癌的分子特征.方法:回顾性对2013年7月至2016年12月13例病理确诊并接受治疗的肺黏液表皮样癌临床特征和分子特点进行分析.结果:EGFR基因突变率为15.38%(2/13),且2例均为L861Q点突变,EGFR基因状态与性别(P=1.000)、年龄(P=1.000)、吸烟史(P=0.848)及分期(P=1.000)均无相关性;MAML2融合基因阳性率为45.45%(5/11),MAML2融合基因状态与性别(P=0.521)、年龄(P=0.521)、吸烟史(P=1.000)及分期(P=0.924)均无相关性(P>0.05).结论:肺黏液表皮样癌中EGFR基因最常见的突变为L861Q,EGFR基因野生型患者中存在MALM2基因融合.
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| 关 键 词： | 肺黏液表皮样癌 分子特征 EGFR基因 MAML2基因 |
Molecular features of pulmonary mucoepidermoid carcinoma |
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| ZHUANG Wu,WANG Wenxian,LIN Xueping,HUANG Yunjian,XU Chunwei,CHEN Yanping,FANG Meiyu,ZHU Youcai,LU Yan,CHEN Gang. Molecular features of pulmonary mucoepidermoid carcinoma[J]. Journal of International Pathology and Clinical Medicine, 2017, 37(7). DOI: 10.3978/j.issn.2095-6959.2017.07.010 |
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| Authors: | ZHUANG Wu WANG Wenxian LIN Xueping HUANG Yunjian XU Chunwei CHEN Yanping FANG Meiyu ZHU Youcai LU Yan CHEN Gang |
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| Abstract: | Objective: To investigate the molecular characteristics of pulmonary mucoepidermoid carcinoma (PMEC). Methods: From July 2013 to December 2016, 13 PMEC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state.Results:EGFR mutation rate was 15.38% (2/13), and 2 cases were both L861Q point mutations, the relationship betweenEGFR gene status and gender (P=1.000), age (P=1.000), smoking (P=0.848) and stage (P=1.000) were no significant; the positive rate ofMAML2 fusion gene was 45.45% (5/11). the relationship betweenMAML2 fusion gene status and gender (P=0.521), age (P=0.521), smoking (P=1.000) and stage(P=0.924) were all no signiflcant. Conclusion:The most common form change of pulmonary mucoepidermoid carcinoma wasEGFR gene L861Q point mutation, MALM2 fusion gene exist in theEGFR gene wild type patients. |
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| Keywords: | pulmonary mucoepidermoid carcinoma molecular features EGFR gene MAML2 gene |
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