| 肺鳞状细胞癌EGFR/ALK的基因状态 |
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| 引用本文： | 庄武,钟礼花,陈芳芳,陈燕坪,黄韵坚,黄章洲,卢建平,王晓江,师怡,林贤东,许春伟,陈刚. 肺鳞状细胞癌EGFR/ALK的基因状态[J]. 国际病理科学与临床杂志, 2017, 37(5). DOI: 10.3978/j.issn.2095-6959.2017.05.019 |
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| 作者姓名： | 庄武 钟礼花 陈芳芳 陈燕坪 黄韵坚 黄章洲 卢建平 王晓江 师怡 林贤东 许春伟 陈刚 |
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| 作者单位： | 1. 福建医科大学附属福建省肿瘤医院胸部肿瘤内科,福州,350014;2. 福建医科大学附属福建省肿瘤医院病理科,福州,350014 |
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| 基金项目： | 国家临床重点专科建设项目，福建省科技厅引导性项目(2015Y0011;2016Y0019).This work was supported by National Clinical Key Specialty Construction Program，Leading Project Foundation of Science Department of Fujian Province，China |
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| 摘 要： | 目的:探讨肺鳞状细胞癌各亚型中EGFR和ALK的基因状态.方法:应用ARMS方法检测肺鳞状细胞癌石蜡组织中EGFR基因突变和ALK融合基因情况.结果:218例肺鳞状细胞癌样本中,E GFR基因突变率为4.59％(10/218),19del和L858R各为2.29％(5/218).ALK融合基因阳性率为6.14％(7/114).结论:肺鳞状细胞癌存在一定比例EGFR基因突变和ALK融合基因阳性,肺鳞状细胞癌EGFR基因和ALK融合基因常规检测不可忽视.
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| 关 键 词： | 鳞状细胞癌 EGFR基因 ALK基因 突变率 |
EGFR/ALK gene status of lung squamous cell carcinoma |
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| ZHUANG Wu,ZHONG Lihua,CHEN Fangfang,CHEN Yanping,HUANG Yunjian,HUANG Zhangzhou,LU Jianping,WANG Xiaojiang,SHI Yi,LIN Xiandong,XU Chunwei,CHEN Gang. EGFR/ALK gene status of lung squamous cell carcinoma[J]. Journal of International Pathology and Clinical Medicine, 2017, 37(5). DOI: 10.3978/j.issn.2095-6959.2017.05.019 |
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| Authors: | ZHUANG Wu ZHONG Lihua CHEN Fangfang CHEN Yanping HUANG Yunjian HUANG Zhangzhou LU Jianping WANG Xiaojiang SHI Yi LIN Xiandong XU Chunwei CHEN Gang |
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| Abstract: | Objective:To investigate the mutations of EGFR gene and ALK fusion gene in lung squamous cell carcinoma.Methods:The ARMS method was used to detect the tissues in 218 patients of lung squamous cell carcinoma with paraffin tissue EGFR gene mutation and ALK fusion gene.Results:The total mutation rate in 218 patients of squamous cell carcinoma was 54.71％(151/276).EGFR gene mutation rate was 2.29％ (5/218),which was both found in 19del and L858R,ALK fusion gene positive rate was 6.14％ (7/114).Conclusion:There are a certain proportion ofEGFR gene mutation and ALK fusion gene in lung squamous cell carcinoma,and the detection the EGFR gene mutation and ALK fusion gene can not be ignored in squamous cell carcinoma. |
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| Keywords: | squamous cell carcinoma EGFR gene ALK gene mutation rate |
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