| 人角质形成细胞在皮肤光老化中的研究进展 |
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| 引用本文： | 李艳飞,木其日,其木格,莎娜. 人角质形成细胞在皮肤光老化中的研究进展[J]. 国际皮肤性病学杂志, 2017, 43(3). DOI: 10.3760/cma.j.issn.1673-4173.2017.03.008 |
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| 作者姓名： | 李艳飞 木其日 其木格 莎娜 |
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| 作者单位： | 内蒙古自治区人民医院皮肤性病科, 呼和浩特,010010 |
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| 基金项目： | 内蒙古自治区人民医院基金(201556) Inner Mongolia People′s Hospital Fund |
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| 摘 要： | 光老化是长期紫外线照射导致的慢性炎性损伤,其中长波紫外线和中波紫外线红外线可诱导皮肤损伤引起光老化,但其发病机制尚未完全明确.人角质形成细胞是表皮中重要的细胞,也是紫外线敏感的靶细胞.近年来研究表明,人角质形成细胞在光老化的发生和发展中起重要作用.其中衰老自由基学说最为热门,抗老化的机制和药物、植物等方面的研究也多从此方面入手.
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| 关 键 词： | 光 紫外线 细胞衰老 角蛋白细胞 基质金属蛋白酶类 细胞凋亡 |
Role of human keratinocytes in skin photoaging |
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| Li Yanfei,Mu Qiri,Qi Muge,Sha Na. Role of human keratinocytes in skin photoaging[J]. International Journal of Dermatology and Venereology, 2017, 43(3). DOI: 10.3760/cma.j.issn.1673-4173.2017.03.008 |
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| Authors: | Li Yanfei Mu Qiri Qi Muge Sha Na |
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| Abstract: | Photoaging is a kind of chronic inflammatory injury induced by long?term ultraviolet radiation exposure. Ultraviolet A and ultraviolet B both can cause skin damage followed by photoaging, but the pathogenesis is still unclear.Human keratinocytes are the most important cells in the epidermis, and also are target cells sensitive to ultraviolet rays. Recent researches have shown that keratinocytes play an important role in the occurrence and development of photoaging. Among related theories, the free radical theory of aging is the most popular, and researches on anti?aging mechanisms, related medicines and plants are usually based on this theory. |
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| Keywords: | Light Ultraviolet rays Cell aging Keratinocytes Matrix metalloproteinases Apoptosis |
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