中性粒细胞胞外诱捕网在动脉粥样硬化中的研究进展

动脉粥样硬化作为一种炎症反应性疾病,已成为心脑血管病领域的共识.而参与动脉粥样硬化炎症反应的细胞成分多种多样,包括单核-巨噬细胞、树突状细胞、T淋巴细胞及中性粒细胞等.中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是中性粒细胞活化时释放的网状物质,它具有抗炎、促炎、促凝等多种生物活性,并参与多种疾病的病理进程.研究发现:中性粒细胞可以在某些刺激因子作用下活化并释放出NETs,而NETs具有细胞毒性和血栓形成效应,并且能够与巨噬细胞产生交互作用,它作为将炎症和血栓形成联系起来的桥梁,在动脉粥样硬化的病理进程中发挥了重要作用.

Research progress of neutrophil extracellular traps in atherosclerosis

It has become a consensus in the field of cardio-cerebrovascular disease that atherosclerosis is an inflammatory response disease,and inflammation cells involved in atherosclerotic are varied,including mononuclearmacrophages,dendritic cells,T lymphocytes and neutrophils,etc.Neutrophil extracellular traps (NETs) are mesh structure released by activated neutrophils.They have diverse biological activities,such as anti-inflammatory and proinflammatory effect,procoagulant activity.They also participate in pathological processes of many kinds of diseases.A number of studies found that neutrophils can be activated by some stimulating factor and release NETs.NETs have cytotoxic and pro-thrombotic effects,and the ability to interact with macrophages,they play an important role in atherosderosis pathology as a link between inflammation and thrombosis.