七氟醚对心肌缺血/再灌注损伤的临床研究进展

背景 七氟醚的心肌保护作用得到广泛关注,大量基础研究表明七氟醚对心肌缺血/再灌注损伤(myocardial ischemia/reperfusion injury,MI/RI)具有确切的保护作用.然而,临床中关于七氟醚具有心肌保护作用的结论尚未完全统一.目的 通过总结近年的研究进展对七氟醚的心肌保护作用进行阐述.内容 不同心脏手术及非心脏手术中七氟醚药物处理的心肌保护效果.趋向 今后仍需加强对七氟醚心肌保护作用的临床研究,为围手术期患者的心肌保护提供更为可靠的理论依据.

Protective effects of sevoflurane on myocardial ischemia/reperfusion injury

Background As a common anesthetics, sevoflurane has been demonstrated by numerous experimental research to prevent myocardial ischemia/reperfusion injury (MI/RI). However, this benefit has not been consistently supported by clinical studies. Objective To review recent clinical research to evaluate myocardial protection of sevoflurane. Content Sevoflurane may protect myocardia from MI/RI during heart and non-heart surgery, including coronary artery bypass grafting, heart valve surgery, cardiac intervention therapy, and esophagectomy, etc. The efficacy depends on timing, duration, concentration, types of surgery, and health status of patients. Trend The diversity of surgeries that use sevoflurane for anesthetics posits difficulty in reaching consent about myocardial protection in MI/RI by sevoflurane. Large-scale, multi-center, double-blind, randomized clinical investigations are demanded to solve this puzzle.