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| 动力相关蛋白1的小泛素化相关修饰物化修饰在脑缺血/再灌注损伤中的作用 | |
| 引用本文： | 张高峰,尹曾,陈怀龙,李秋杰,张照亮,时飞,王明山. 动力相关蛋白1的小泛素化相关修饰物化修饰在脑缺血/再灌注损伤中的作用[J]. 国际麻醉学与复苏杂志, 2017, 38(8). DOI: 10.3760/cma.j.issn.1673-4378.2017.08.020 |
| 作者姓名： | 张高峰 尹曾 陈怀龙 李秋杰 张照亮 时飞 王明山 |
| 作者单位： | 青岛市市立医院东院麻醉科,266071 |
| 基金项目： | Natural Science Foundation of Shandong Province(ZR2015HM023)山东省自然科学基金 |
| 摘 要： | 背景 近年研究发现动力相关蛋白1(dynamin-related protein 1,Drp1)介导的线粒体分裂在脑缺血/再灌注损伤(cerebral ischemia/reperfusion injury,CI/RI)中发挥了重要作用,Drp1的小泛素化相关修饰物(small ubiquitin-related modifier,SUMO)化修饰能影响自身生物学效应.目的 阐述Drp1的SUMO化修饰在CI/RI中的作用.内容 分别描述Drp1蛋白、SUMO蛋白、SUMO相关酶(SUMO化酶/去SUMO化酶)及SUMO化修饰对Drp1生物学效应的影响.趋向 研究SUMO化修饰影响Drp1的生物学效应的机制,为减轻或治疗CI/RI找到新的靶点或提供新的思路. |
| 关 键 词： | 动力相关蛋白1 小泛素化相关修饰物 线粒体分裂 凋亡 缺血/再灌注损伤 |
Post-translational modification of dynamin-related protein 1 by small ubiquitin-related modifier in cerebral ischemia/reperfusion injury |
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| Zhang Gaofeng,Yin Zeng,Chen Huailong,Li Qiujie,Zhang Zhaoliang,Shi Fei,Wang Mingshan. Post-translational modification of dynamin-related protein 1 by small ubiquitin-related modifier in cerebral ischemia/reperfusion injury[J]. international journal of anesthesiology and resuscitation, 2017, 38(8). DOI: 10.3760/cma.j.issn.1673-4378.2017.08.020 | |
| Authors: | Zhang Gaofeng Yin Zeng Chen Huailong Li Qiujie Zhang Zhaoliang Shi Fei Wang Mingshan |
| Abstract: | Background Mitochondrial fission mediated by dynamin-related protein 1 (Drp1) plays an important role in cerebral ischemia/reperfusion injury (CI/RI),and biological effects of Drp1 are altered by small ubiquitin-related modifier(SUMO) through SUMOylation.Objective To investigate the effects of Drp1 SUMOylation on CI/RI.Content Drp1 belongs to dynamin family,and its upregulation correlates with the fission of mitochondrial,a critical process in apoptosis.SUMOylation and deSUMOylation are a pair of opposite procedures in post-translational modification of Drp1,respectively attenuating and enhancing the binding of Drp1 with mitochondrial.The balance between SUMOylation and deSUMOylation determines the damages following CI/RI.Trend Stabilizing or promoting SUMOylation of Drp1 could be a novel strategy to limit the damage of CI/RI. |
| Keywords: | Dynamin-related protein 1 Small ubiquitin-related modifier Mitochondrial fission Apoptosis Ischemia/reperfusion injury |
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