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| 肝康颗粒对小鼠急性酒精性肝损伤的保护作用 | |
| 引用本文： | 于海玲,郭建鹏,李迎军,张倩,全顺花,李迎春,崔慧艳. 肝康颗粒对小鼠急性酒精性肝损伤的保护作用[J]. 延边医学院学报, 2010, 33(1): 13-15 |
| 作者姓名： | 于海玲 郭建鹏 李迎军 张倩 全顺花 李迎春 崔慧艳 |
| 作者单位： | 于海玲,李迎军,张倩,全顺花,李迎春,崔慧艳(延边大学基础医学院,机能学实验中心);郭建鹏(延边大学药学院,药剂学教研室;延边大学,长白山生物资源与功能分子教育部重点实验室,吉林,延吉,133000) |
| 基金项目： | 吉林省科技发展计划项目200705422 |
| 摘 要： | [目的]探讨肝康颗粒对小鼠酒精性肝损伤的保护作用.[方法]分别灌胃给予不同组的小鼠东宝甘泰及5.85,11.70,23.40 g/kg剂量肝康颗粒,连续5 d,除正常组外其余均灌胃给予500 mL/L乙醇制作小鼠急性酒精性肝损伤模型,禁食不禁水12 h后测定血清丙氨酸转氨酶(ALT)活性、肝组织丙二醛(MDA)及还原型谷胱甘肽(GSH)含量.[结果]肝康颗粒大、中剂量组小鼠肝脏指数及肝组织MDA含量明显降低;肝康颗粒大、中、小剂量组肝GSH活性明显升高,血清ALT活性无显著变化.[结论]肝康颗粒对小鼠急性酒精性肝损伤具有一定的保护作用. |
| 关 键 词： | 中成药 酒精中毒 肝疾病 小鼠 |
Protective effects of the Gankang granules on acute alcohol-induced liver injury in mice |
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| YU Hai-ling,GUO Jian-peng,,LI Ying-jun,ZHANG Qian,QUAN Shun-hua,LI Ying-chun,CUI Hui-yan. Protective effects of the Gankang granules on acute alcohol-induced liver injury in mice[J]. Journal of Medical Science Yanbian University, 2010, 33(1): 13-15 | |
| Authors: | YU Hai-ling GUO Jian-peng LI Ying-jun ZHANG Qian QUAN Shun-hua LI Ying-chun CUI Hui-yan |
| Affiliation: | YU Hai-ling1,GUO Jian-peng2,3,LI Ying-jun1,ZHANG Qian1,QUAN Shun-hua1,LI Ying-chun1,CUI Hui-yan1(1.Teaching Center of Functional Experimental Science,Yanbian University College of Basic Medicine,2.Department of Pharmacy,Yanbian University College of Pharmacy,3.Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules,Yanbian University,Ministry of Education:Yanji 133000,Jilin,China) |
| Abstract: | OBJECTIVE To study the protective effects of the Gankang granules on alcohol-induced liver injury in mice.METHODSThe Dongbaogantai and 5.85,11.70,23.40g/kg of Gankang granules were performed by intragastric administration in different groups for five days,respectively,and in addition to the normal group,the remaining groups were given by oral administration of ethanol 500mL/L to replicate acute alcohol-induced liver injury model.After absolute diet and no water fasting for 12 hours,the alanine aminotransfer... |
| Keywords: | Chinese patent drugs alcoholism liver diseases mice |
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