苦参碱及氧化苦参碱抗肿瘤作用的研究进展

苦参是豆科植物苦参的干燥根,作为其主要成分的苦参碱和氧化苦参碱具有抗炎、抗心律失常及抗病毒的功效.其还具有肿瘤杀伤作用,其抗肿瘤活性主要表现在抑制肿瘤细胞的增殖转移、诱导肿瘤细胞的分化与凋亡,抑制端粒酶的活性、抑制肿瘤新生血管的形成、抑制肿瘤耐药性及促进宿主抗肿瘤免疫反应等.此外研究证实,苦参碱和氧化苦参碱在临床上能明显改善患者的恶病质状态,提高患者生活质量.通过对苦参碱及氧化苦参碱的对比研究发现,两者由于分子构象差异使得氧化苦参碱的药理活性要大于苦参碱,因而加强对氧化苦参碱的研究是有必要的.苦参碱及氧化苦参碱为天然植物药物,疗效切实,进一步的研究将会为新药的研发及应用提供有价值的方向.

Progress of Research and Application in Tumors of Matrine and Oxymatrine

The Chinese traditional medicine sophora avescens aiton is the dry root of leguminous plant radix sophorae flavescentis, the early researches showed that, as the main active component, matrine and oxymatrine have the functions of anti-inflammation, arrhythmia and, anti-virus. Further studies found that they also can kill tumors, and its antitumor activity mainly displays in inhibiting proliferation and metastasis, inducing differentiation and apoptosis, promoting apoptosis, inhibiting telomerase activity,inhibiting the formation of new blood vessels, inhibiting the drug resistance, promoting antitumor immune response of the host and so on. In addition, studies confirm that matrine and oxymatrine can obviously improve the cachexia state and improve the patients' quality of life. Matrine and oxymatrine are natural plant drugs, curative effect practicaly, has the important research and application value.