Interim report on a method of extracorporeal perfusion of preserved canine kidney

Summary The early renal function after preservation with cold C3 Collins solution has been studied by means of kidney perfusion on a high-flow external arteriovenous shunt. With this technique, the authors have been able to establish that a measurable GFR is almost immediatly reached after connection even if some tubular impairment is present, and if the O₂ consumption reduced. At microscopy, normal glomeruli and peculiar tubular vacuolization have been seen, probably an expression of ischaemic damage. The experimental model has proved very simple and suitable for many other studies.