血栓抽吸治疗在急性ST段抬高心肌梗死直接介入治疗中应用的安全性和有效性研究

目的:评价血栓抽吸治疗在急性ST段抬高心肌梗死(STEMI)直接经皮冠状动脉介入治疗术(PCI)中应用的安全性和有效性.方法:59例STEMI患者被随机分为血栓抽吸组和传统PCI组(对照组),对2组之间的冠状动脉造影结果(TIMI 3级血流率、校正TIMI帧数、TMP分级)、心电图ST段回落百分比(sumSTR)和临床结果肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)峰值、术后1周左室射血分数(LVEF)、6个月主要不良心血管事件]进行分析比较.结果:血栓抽吸组PCI后梗死相关动脉TIMI 3级血流率、TMP3级及sumSTR>70%发生率均显著高于对照组,校正TIMI帧数、TMP0～1级及sumSTR<30%均显著低于对照组.血栓抽吸组CK、CK-MB峰值显著低于对照组 ,术后1周LVEF显著高于对照组.随访6个月主要不良心血管事件2组差异无统计学意义.结论:在急性STEMI直接PCI中应用血栓抽吸治疗是安全有效的,能够改善心肌灌注,降低心肌梗死面积,提高LVEF.

Study on safety and efficiency of thrombus aspiration during primary PCI for acute ST-segment elevation myocardial infarction

Objective:This study attempts to investigate the safety and efficiency of thrombus aspiration during primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction.Method:A total of 59 patients were assigned to the thrombus-aspiration group or the conventional-PCI group.We assessed angiographic (TIMI Ⅲ blood flow, corrected TIMI frame, TMP grade) and electrocardiographic signs(sum-STR) of myocardial reperfusion, as well as clinical outcome (peak values of CK and CK-MB,LVEF in one week after PCI, clinical outcomes up to 6 months after PCI). Result:The thrombus-aspiration group had a significantly higher rate of post-procedural TIMI III blood flow as compared with conventional-PCI group (P=0.033). The thrombus-aspiration group had a significantly lower corrected TIMI frame number as compared with conventional-PCI group (P=0.001). Patients in thrombus-aspiration group had a higher rate of TMP grade 3 blood flow after PCI (P=0.007) while a lower rate of TMP grade 0-1 blood flow (P=0.030) as compared with those in conventional-PCI group. More patients in thrombus-aspiration group had sumSTR>70% (P=0.019) at 1 hour after PCI,while fewer patient in thrombus-aspiration group had sum STR<30% (P=0.030) as compared with those in conventional-PCI group. Patients in the thrombus-aspiration group had significantly lower peak values of CK and CK-MB as compared with those in conventional-PCI group (P<0.001). Patients in the thrombus-aspiration group had significantly higher LVEF (P=0.001) in a week after PCI as compared with those in conventional-PCI group. Clinical outcomes up to 6 months after PCI were no significant difference between two groups. Conclusion:Thrombus aspiration is applicable in patients with myocardial infarction with ST-segment elevation, and it results in better reperfusion higher LVEF and clinical outcomes than conventional PCI.