| 中枢乙酰胆碱和5-羟色胺在针刺镇痛中的作用 |
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| 引用本文： | 汤健,涂宗萍,任民峰,韩济生. 中枢乙酰胆碱和5-羟色胺在针刺镇痛中的作用[J]. 针刺研究, 1980, 0(1) |
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| 作者姓名： | 汤健 涂宗萍 任民峰 韩济生 |
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| 作者单位： | 北京医学院基础部针麻原理研究组生理组，武汉医学院生理教研组，北京医学院基础部针麻原理研究组生理组，北京医学院基础部针麻原理研究组生理组 |
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| 摘 要： | <正> 我们曾经报告,脑内乙酰胆碱和5-羟色胺在针刺镇痛过程中都具有重要作用。应用密胆碱(HC-3)阻断脑内乙酰胆碱合成,可以明显降低针效;若在此基础上补充胆碱,又可使针效恢复。应用对氯苯丙氨酸(pCPA)阻断脑内5-羟色胺的合成,针效亦明显降低;相反,应用5-羟色氨
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THE ROLE OF CENTRAL 5-HYDROXYTRYPTAMINE AND ACETYLCHOLINE IN ACUPUNCTURE ANALGESIA |
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| Abstract: | The role played by central 5-hydroxytryptamine(5-HT)and acetylcholine(ACh)in Acupunc-ture Analgesia(AA)has been studied in rats.Blocking of synthesis of ACh by intraventricular injection of hemicholine(HC-3)reduced theeffect of AA following the lowering of the 5-HT and 5-HIAA content in the central nervoussystem.The blocking effect of HC-3 on AA could be reversed by choline,the precursor of ACh,followingthe increasing of central 5-HT and 5-HIAA.The blocking effect of HC-3 could also be reversed by the injection of 5-Hydroxytryptophan(5-HTP)to increase the content of central 5-HTFrom the results stated above,it follows that central ACh and 5-HT seem to be the importantfactors mediating the acupuncture analgesia,but the effect of ACh on AA might possibly bemediated through the effect of central 5-HT. |
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