短期化疗对兔腹主动脉顺应性的影响

目的 比较短期化疗前后兔腹主动脉顺应性的变化，了解化疗药物对血管力学特性的影响。方法将15只新西兰兔随机等分为5组，其中4组接受1周期化疗（卡铂100mg／m^2，第1、3、5天；异环磷酰胺1500mg／m^2，第1、3、5天；足叶乙贰100mg／m^2，第l～3天），另1组为对照组。分别测量各组兔腹主动脉比顺应性（化疗组分为化疗后第2、7、14、21天进行观察）。结果短期化疗前后兔腹主动脉顺应性显著变化，化疗后第14天下降最明显，而第21天则基本恢复。结论短期化疗能够降低兔腹主动脉比顺应性，降低的程度与化疗后时间相关，并具有可逆行性。

Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta

Objective To investigate the effect of short-term chemotherapy on the compliance of rabbit abdominal aorta, and understand the changes in the biomechanical properties of the blood vessels after chemotherapy. Methods Fifteen rabbits were divided into 5 groups, 4 of which were subjected to injection with chemotherapeutic agents for 5 days to evaluate the compliance of the abdominal aorta at 2, 7, 14, and 21days after the therapy with the other group without chemotherapy serving as the control. Results The compliance of the abdominal aorta was obviously decreased after chemotherapy and reached the lowest level 14 days after short-term chemotherapy, suggesting that the drugs resulted in vascular injury enough toalter the biomechanical properties of the blood vessels. Conclusion Short-term chemotherapy can decrease the compliance of the blood vessels, which may deteriorate with time but such changes can be reversible.