| 表皮生长因子受体与酪氨酸激酶抑制剂在肿瘤防治中的应用进展 |
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| 引用本文： | 张敏,张新,白春学. 表皮生长因子受体与酪氨酸激酶抑制剂在肿瘤防治中的应用进展[J]. 中国癌症杂志, 2003, 13(3): 275-278 |
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| 作者姓名： | 张敏 张新 白春学 |
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| 作者单位： | 复旦大学附属中山医院肺科,上海,200032 |
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| 基金项目： | 上海市科技发展基金(No.0 2DJ14 0 2 7) |
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| 摘 要： | 表皮生长因子受体(epidermal growth factor receptor,EGFR)信号传递系统可调控细胞周期，调节细胞生长与分化，促进损伤修复。EGFR在包括非小细胞肺癌(non-small-cell lung cancer,NSCLC)在内的多种上皮源性肿瘤中过表达预示存活率低、预后差、转移可能性大，可作为肿瘤基因治疗的靶位。酪氨酸激酶抑制剂(tyrosine kinase inhibitors，TKIs)可选择性抑制EGFR酪氨酸激酶活性，抑制肿瘤生长，增加放化疗敏感性。
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| 关 键 词： | 表皮生长因子受体 酪氨酸激酶抑制剂 肿瘤 防治 应用 |
| 文章编号： | 1007-3639(2003)03-0275-04 |
| 修稿时间： | 2002-11-19 |
Progress of epidermal growth factor receptor and tyrosine kinase inhibitors in the cancer therapy |
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| ZHANG Min,ZHANG Xin,BAI Chun xue. Progress of epidermal growth factor receptor and tyrosine kinase inhibitors in the cancer therapy[J]. China Oncology, 2003, 13(3): 275-278 |
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| Authors: | ZHANG Min ZHANG Xin BAI Chun xue |
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| Abstract: | The signal transduction system induced by epidermal growth factor receptor(EGFR) regulates cell cycle ,modulates cell growth and differentiation and improves damage repair.The overexpression of EGFR in several epithelial tumors including non small cell lung cancer(NSCLC) forecasts low survival rate, poor prognosis and metastasis. Thereby EGFR can be a potential target for gene therapy. Tyrosine kinase inhibitors(TKIs) selectively inhibit tyrosine kinase activity,supress tumor growth ,and increase the sensitivity of radio chemotherapy. [ |
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| Keywords: | epidermal growth factor receptor signal transduction system non small cell lung cancer tyrosine kinase inhibitors |
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