维生素D与自身免疫性甲状腺疾病

近年来较多的研究表明,维生素D具有调节免疫的特性,在一些自身免疫性疾病动物模型中表现出一定的防治作用.自身免疫性甲状腺疾病(AITD)是一种器官特异性自身免疫性疾病.研究证实,维生素D相关基因多态性与AITD相关,如维生素D受体基因、1α-羟化酶(CYP2781)基因、维生素D结合蛋白基因等.AITD患者存在维生素D缺乏,一些研究表明应用维生素D对AITD具有一定的防治作用.维生素D及其类似物防治AITD的可能机制在于它们能够调节AITD患者的细胞因子表达,并对其甲状腺细胞凋亡具有调节作用.因此认为,维生素D及其类似物在AITD的临床应用前景广阔.

Vitamin D and autoimmune thyroid disease

In recent years,the role of vitamin D in the immune system has been investigated. The immunomodulatory properties of vitamin D compounds were illustrated by their ability to either prevent or suppress animal models of autoimmune disease. Autoimmune thyroid diseases (AITD) are organ-specific an-toimmune diseases. It was testified that AITD were associated with the polymorphisms of vitamin D related genes, such as vitamin D receptor gene,25-hydroxyvitamin D3-1α-hydroxylase (CYP27B1) gene, vitamin D-binding protein gene, etc. Patients with AITD were coexisted with vitamin D deficiency and vitamin D supple-mentation benefited for the prevention and treatment of AITD. The probable mechanisms of vitamin D and its analogs in AITD maybe include modulating the expression of many cytokines in AITD and regulating apopto-sis of thyroid cells. Thus we postulate that vitamin D and its analogs have a broad prospect in the clinical ap-plication for AITD.