Allograft rejection after living-related simple limbal epithelial transplantation |
| |
| Authors: | Jayesh Vazirani Sayan Basu Virender S Sangwan |
| |
| Institution: | Center for Excellence in Cornea and Ocular Surface Disorders, Excel Eye Care, Ahmedabad, Gujarat, India;1.Centre for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, Telangana, India;2.The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India;3.Dr. Shroff''s Charity Eye Hospital, New Delhi, India |
| |
| Abstract: | A 23-year-old man presented with congestion, peripheral corneal vascularization, an elevated ridge-like epithelial line and cellular infiltration around limbal transplants, 15 months after undergoing living-related simple limbal epithelial transplantation (SLET) for total limbal stem cell deficiency. A diagnosis of acute allograft rejection was made and he was treated with intravenous methylprednisolone, topical and oral prednisolone as well as systemic cyclosporine and azathioprine, leading to reversal of the signs. Similar findings were noted during a later rejection episode. An epithelial rejection line and cellular infiltration of limbal transplants are easily identifiable clinical signs of allograft rejection post SLET. |
| |
| Keywords: | Allograft rejection epithelial rejection line immunosuppression simple limbal epithelial transplantation |
|
|
