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Jab1在喉鳞状细胞癌中的表达及临床意义
引用本文:张锋,曹华. Jab1在喉鳞状细胞癌中的表达及临床意义[J]. 山东医大基础医学院学报, 2007, 0(2)
作者姓名:张锋  曹华
作者单位:郑州大学第一附属医院耳鼻咽喉科 河南郑州450052
摘    要:
目的:探讨Jab1在喉鳞状细胞癌(LSCC)中的表达及其与LSCC临床病理和预后的关系。方法:采用免疫组化SP法检测23例正常喉黏膜(NLT)和72例LSCC组织中Jab1的表达。结果:在54.17%的LSCC中Jab1呈现过表达,并且与临床分期和淋巴结转移呈显著正相关,与患者的总生存率呈负相关(P<0.05)。结论:Jab1可能通过调节p27kip1蛋白的降解而参与LSCC的发生、发展,Jab1可以作为LSCC的一个预后指标。

关 键 词:喉肿瘤    鳞状细胞  免疫组织化学  Jab1

Expression of Jab1 in laryngeal squamous cell carcinoma
ZHANG Feng,CAO Hua. Expression of Jab1 in laryngeal squamous cell carcinoma[J]. Journal of Preclinical Medicine College of Shandong Medical University, 2007, 0(2)
Authors:ZHANG Feng  CAO Hua
Abstract:
Objective: To study the expression of Jab1(c-Jun activation domain-binding protein 1) in laryngeal squamous cell carcinoma(LSCC) and its correlation with clinicopathologic variables and prognosis.Methods: Expression of Jab1 protein was determined by SP immunohistochemistry in 23 cases of normal laryngeal tissues and 72 cases of LSCC.Results: Jab1 over-expression was produced in 54.17% of LSCC and was significantly positively associated with clinicopathologic variables and lymph node metastasis.Survival analysis revealed that Jab1 over-expression was significantly negatively associated with the overall survival(P<0.05).Conclusions: Jab1 protein may contribute to the development and progression of LSCC by facilitating the degradation of p27kip1 and represents a novel prognostic indicator for LSCC.
Keywords:Laryngeal neoplasms  Carcinoma  squamous cells  Immunohistochemistry  Jab1
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