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| 荧光原位杂交技术的妇产科应用进展 | |
| 引用本文： | 彭玉池（综述）,凌斌（审校）. 荧光原位杂交技术的妇产科应用进展[J]. 国外医学:妇产科学分册, 2009, 36(1): 34-37 |
| 作者姓名： | 彭玉池（综述） 凌斌（审校） |
| 作者单位： | 安徽医科大学附属省立医院妇产科分子实验室; |
| 基金项目： | 卫生部医药卫生科技发展中心(WKJ2007-3-001) |
| 摘 要： | 荧光原位杂交（FISH）技术是一门新兴的分子细胞学遗传技术，具有快速、安全、简便、高灵敏度、高特异性及多色等优点，已经广泛应用于分子细胞遗传学检测、间期细胞遗传学分析以及DNA片段的染色体定位等研究中。推动了临床细胞遗传学的发展。随着细胞遗传学研究技术的不断深入，在FISH技术上建立了比较基因组杂交技术（CGH）、微阵列比较基因组杂交技术（arrayCGH）。目前FISH技术在产前诊断、植入前遗传学诊断、妇科肿瘤相关基因诊断和分析中展现出更加广阔的应用前景。从FISH技术探针的类型、标记方法及在妇产科领域的应用做简要综述。 |
| 关 键 词： | 荧光原位杂交技术 比较基因组杂交技术 微阵列 产前诊断 植入前遗传学诊断 |
Progress in the Use of Fluorescent in Situ Hybridization in Obstetrics and Gynecology |
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| PENG Yu-chi,LING Bin.Molecular Laboratory of. Progress in the Use of Fluorescent in Situ Hybridization in Obstetrics and Gynecology[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 36(1): 34-37 | |
| Authors: | PENG Yu-chi LING Bin.Molecular Laboratory of |
| Affiliation: | PENG Yu-chi,LING Bin.Molecular Laboratory of Department of Obsterics , Gynecology of Anhui Provincial Hospital,Anhui Medi-cal University,Hefei 230001,China |
| Abstract: | Fluorescent in situ hybridization(FISH)is a new and developing molecular cytogenetic approach with a number of advantages over conventional approaches,including improved speed,safety,sensitivity,specificity,and ease-of-use,and is able to employ multiple colors.FISH has been applied in molecular cytogenetic detection,interval molecular cytogenetic analysis,and DNA fragment chromosome mapping,and is improving clinical cyto-genetics.The use of comparative genomic hybridization and microarray comparative genomi... |
| Keywords: | Fluorescent in situ hybridization Comparative genomic hybridization Microarray Prenatal diagnosis Preimplantation genetic diagnosis |
| 本文献已被 CNKI 维普 等数据库收录！ | |