整合素介导的细胞信号转导与肿瘤辐射敏感性

整合素作为重要的细胞黏附分子,可介导细胞的信号转导,在细胞的黏附、迁移、增殖、分化等生长活动中发挥重要作用。同时,在电离辐射条件下,整合素介导的细胞信号转导可在肿瘤细胞内激活多种蛋白激酶,启动不同的信号通路,调控基因表达,维持肿瘤细胞的存活,降低肿瘤的辐射敏感性。因此,深入了解整合素及其所介导的细胞信号转导途径,有利于新型辐射增敏剂的研究,对肿瘤治疗具有积极意义。

Signal transduction pathway mediated by integrin and tumor radiosensitivity

Integrins are a group of significant cell adhesion molecules and participate in the regulation of critical functions through cellular signal trusduction, including cell adhesion, migration, proliferation, differentiation, and so on. The integrin-mediated signaling, meanwhile, may activate a variety of protein kinases after ionizing radiation, and then form different intracellular signal pathways in order to regulate the expression of gene. As consequence, these signal pathways induce the reduction of the radiosensitivity of tumor cells for survival event. To understand integrin-mediated signal trasduciton, therefore, has the vital influence on the study of radiosensitizer and radiotherapy.