| 炔诺酮-α、β-聚(4-羟丁基)-DL-天冬酰胺高分子药物体外体内释放的研究 |
| |
| 引用本文： | 汤谷平,陈启琪,单达先,洪小珍.炔诺酮-α、β-聚(4-羟丁基)-DL-天冬酰胺高分子药物体外体内释放的研究[J].中国计划生育学杂志,1995(2). |
| |
| 作者姓名： | 汤谷平 陈启琪 单达先 洪小珍 |
| |
| 作者单位： | 浙江医科大学药学系分析化学，浙江医科大学药学系分析化学，浙江医科大学药学系分析化学，浙江医科大学药学系分析化学 杭州 310006，杭州 310006，杭州 310006，杭州 310006 |
| |
| 摘 要： | 本实验对粒度相近载药量不同的炔诺酮-α、β聚(4-羟丁基)-DL-天冬酰胺(NET-PHBA)高分子药物进行体外释放研究。实验表明,释放量与载药量成正比,与药物颗粒大小成反比。同时,对NET-PHBA在兔体内释放作了初步探索。
|
| 关 键 词： | 炔诺酮 聚丁二酰亚胺/功能高分子 体外释放 体内释放 |
Studies on The Polymeric Drug In-Vitro and In-Vivo Release of Norethindrone-α, β-Poly ( 4-Hydroxybutyl )-DL-Asparamide Conju-gates. |
| |
| Tang Gu-ping,et al..Studies on The Polymeric Drug In-Vitro and In-Vivo Release of Norethindrone-α, β-Poly ( 4-Hydroxybutyl )-DL-Asparamide Conju-gates.[J].Chinese Journal of Family Planning,1995(2). |
| |
| Authors: | Tang Gu-ping |
| |
| Institution: | Tang Gu-ping,et al. Department of pharmacy,Zhejiang Medical University Hangzhou,310006. |
| |
| Abstract: | The in-vitro and in-vivo release of NET loading in α, β-poly ( 4-hydroxybutyl )-DL-asparamide conjugates ( NET-PHBA ) was studied. The experiment showed the NET loading had a effect on the rates of in-vitro release. It meant higher NET loading had a faster release. The result of different particle size which had same NET loading showed smaller particles had a faster release than that of larger ones. In order to study the in-vivo release of NET-PHBA,the polymeric drug (10. 9 mg-NET-PHBA per female rabbits , 4-rabbits per group ) was injected muscle of female rabbits weighting 2. 1-2. 5Kg. Column Switching HPLC method was used for determination the serum concentration of NET. |
| |
| Keywords: | Poly-DL-asparamide Norethindrone In-Vitro release In-Vivo release CSHPLC |
| 本文献已被 CNKI 等数据库收录！ |
