海洛因依赖与儿茶酚胺氧位甲基转移酶基因的关联研究

目的：探讨海洛因依赖和儿茶酚胺氧位甲基转移酶（catechol-O-methyltransferase,COMT)基因的关系。方法：应用聚合酶链反应技术检测313例海洛因依赖者和214名正常对照COMT基因108val/met和900Ins C/Del C两个多态性。结果：海洛因依赖者和对照组之间上述两个多态性的基因型和等位基因频率的差异均无显著性（P＞0．05）。结论：COMT基因108val/met和900Ins C/Del C两个多态性均与海洛因依赖无关联。

Association study of heroin dependence and catechol-O-methyltransferase gene

OBJECTIVE: To detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene. METHODS: Genotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls. RESULTS: No differences in genotype and allele frequencies of 108 val/met polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=1.67, P=0.43; allele-wise: chi-square=1.23, P=0.27). No differences in genotype and allele frequencies of 900 Ins C/Del C polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=3.73, P=0.16; allele-wise: chi-square=0.76, P=0.38). CONCLUSION: The results suggested that neither 108 val/met polymorphism nor 900 Ins C/Del C polymorphism of COMT gene was associated with heroin dependence.