| 3-溴丙酮酸对人结肠癌SWIII-C细胞增值和凋亡的影响 |
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| 引用本文： | 刘晓红,王绍志,刘晓梅,等.3-溴丙酮酸对人结肠癌SWIII-C细胞增值和凋亡的影响[J].肿瘤药学,2012(6):411-416,442. |
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| 作者姓名： | 刘晓红 王绍志 刘晓梅 等 |
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| 作者单位： | 南华大学附属第一医院;中南大学基础医学院 |
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| 基金项目： | 国家自然基金项目资助(31200141);湖南省教育厅项目资助(11C1110) |
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| 摘 要： | 目的研究恶性肿瘤患者以及不同感染性疾病患者血清中sMICA分子的含量及临床意义。方法采用ELISA法检测1041例恶性肿瘤及感染性疾病患者和141例正常对照个体血清sMICA分子含量,分析其相关性及诊断价值。结果与正常对照组相比,肝癌患者的血清sMICA含量明显升高(P<0.05)。某些细菌(肠杆菌、结核杆菌、非发酵革兰阴性菌和革兰阳性球菌)、病毒(HBV和HCV)以及梅毒螺旋体感染患者的血清sMICA含量也明显高于正常对照组(P<0.05)。结论血清中sMICA分子含量对肝癌及部分感染性疾病具有一定的辅助诊断价值。肠杆菌、结核杆菌、非发酵革兰阴性菌、革兰阳性球菌、HBV、HCV及梅毒螺旋体感染可导致血清sMICA分子增高。
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| 关 键 词： | MICA sMICA 感染 恶性肿瘤 |
The Changes and Significance of Serum sMICA Protein in Patients with Malignant Tumor or Infectious Diseases |
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| Jiang Xiaoxin,Jiang Yan,Xie Xiaoping,et al..The Changes and Significance of Serum sMICA Protein in Patients with Malignant Tumor or Infectious Diseases[J].Anti-Tumor Pharmacy,2012(6):411-416,442. |
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| Authors: | Jiang Xiaoxin Jiang Yan Xie Xiaoping |
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| Institution: | 1The First Affiliated Hospital of University of South China,Hengyang,Hunan,421001,China;2School of Basic Medical Science,Central South University,Changsha,Hunan,410013,China) |
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| Abstract: | Objective To identify the levels of serum soluble major histocompatibility complex class I chain-related gene A (sMICA) protein in patients with malignant tumor/infectious diseases and explore its clinical significance. Methods The serum sMICA levels were determined by enzyme-linked immunosorbent assay (ELISA), including patients (n=1041) suffering from several types of malignant tumors and infectious diseases and healthy controls (n=141). |
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| Keywords: | MICA sMICA Infection Malignant tumor |
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