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Efficacy of prolonged valganciclovir therapy for congenital cytomegalovirus infection
Authors:Yasuyo Kashiwagi  Hisashi Kawashima  Junya Nakajima  Yu Ishida  Shigeo Nishimata  Tasuku Miyajima  Kouji Takekuma  Akinori Hoshika  Naoki Inoue
Affiliation:(1) Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan;(2) Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan
Abstract:
We report prolonged valganciclovir (VGCV) treatment of a symptomatic cytomegalovirus infection case. Automated auditory brainstem evoked response performed at 5 days of age revealed severe hearing impairment. Cranial magnetic resonance (MR) imaging at 11 days of age showed abnormal findings. At 5 weeks of age, VGCV was started. The viral load in blood cells, plasma, and urine decreased during the 6-week treatment. Because of improvement of hearing level and no adverse effects, VGCV was restarted for an additional 6 weeks. Neither the patient’s hearing impairment nor results of cranial MR imaging have become worse in 6 months. It is crucial to gather information from as many cases as possible treated with VGCV to establish a standard protocol for VGCV treatment.
Keywords:Cytomegalovirus (CMV)  Valganciclovir (VGCV)  Magnetic resonance (MR) imaging  Congenital infection
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