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| Plasma leptin and ghrelin concentrations in patients with Crohn＇s disease | |
| 引用本文： | Nishi Y,Isomoto H,Ueno H,Ohnita K,Wen CY,Takeshima F,Mishima R,Nakazato M,Kohno S. Plasma leptin and ghrelin concentrations in patients with Crohn＇s disease[J]. World journal of gastroenterology : WJG, 2005, 11(46): 7314-7317. DOI: 10.3748/wjg.v11.i46.7314 |
| 作者姓名： | Nishi Y Isomoto H Ueno H Ohnita K Wen CY Takeshima F Mishima R Nakazato M Kohno S |
| 作者单位： | Second Department of Internal MedicineNagasaki University School of Medicine Sakamoto 1-7-1,Nagasaki,Japan,Second Department of Internal MedicineNagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan Department of Endoscopy,Nagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan,Third Department of Internal MedicineMiyazaki Medical College,Kiyotake,Miyazaki,Japan,Second Department of Internal MedicineNagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan,Second Department of Internal MedicineNagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan,Second Department of Internal MedicineNagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan,Third Department of Internal MedicineMiyazaki Medical College,Kiyotake,Miyazaki,Japan,Second Department of Internal MedicineNagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan Department of Endoscopy,Nagasaki University School of Medicine,Sakamoto 1-7-1,Nagasaki,Japan |
| 摘 要： | AIM: To determine the concentrations of leptin and ghrelin, which have opposite effects on appetite, energy expenditure, and weight control, in the plasma of patients with Crohn's disease (CD), which is often associated with weight loss and malnutrition. METHODS: Plasma leptin and ghrelin concentrations were determined in 28 outpatients with CD by radioimmunoassay. Age- and sex-matched controls with and without Helicobacter pylori (H pylori) infection (28 for each) were enrolled in the study. Circulating levels of these hormones were assessed with respect to CD activity, disease localization and medical treatment. RESULTS: There were no significant differences in ghrelin levels between CD patients and H pylori -negative controls. However, circulating ghrelin levels were significantly lower in H pylori-infected subjects than in CD patients and uninfected controls. Plasma leptin levels were comparable among the groups. Localization and medication profile had no significant impact on circulating ghrelin and leptin levels. CONCLUSION: Apart from H pylori infection, CD itself has no significant influence on circulating ghrelin and leptin levels in the outpatients who were mostly in inactive state. |
| 关 键 词： | 等离子体 结肠疾病 临床表现 治疗 |
| 收稿时间： | 2005-07-11 |
Plasma leptin and ghrelin concentrations in patients with Crohn's disease |
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| Nishi Yoshito,Isomoto Hajime,Ueno Hiroaki,Ohnita Ken,Wen Chun Yang,Takeshima Fuminao,Mishima Ryosuke,Nakazato Masamitsu,Kohno Shigeru. Plasma leptin and ghrelin concentrations in patients with Crohn's disease[J]. World journal of gastroenterology : WJG, 2005, 11(46): 7314-7317. DOI: 10.3748/wjg.v11.i46.7314 | |
| Authors: | Nishi Yoshito Isomoto Hajime Ueno Hiroaki Ohnita Ken Wen Chun Yang Takeshima Fuminao Mishima Ryosuke Nakazato Masamitsu Kohno Shigeru |
| Affiliation: | 1. Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1-7-1, Nagasaki, Japan 2. Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1-7-1, Nagasaki, Japan;Department of Endoscopy,Nagasaki University School of Medicine, Sakamoto 1-7-1,Nagasaki, Japan 3. Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake,Miyazaki, Japan 4. Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine,Sakamoto 12-4, Nagasaki, Japan |
| Abstract: | AIM:To determine the concentrations of leptin and ghrelin, which have opposite effects on appetite, energy expenditure, and weight control, in the plasma of patients with Crohn's disease (CD), which is often associated with weight loss and malnutrition. METHODS: Plasma leptin and ghrelin concentrations were determined in 28 outpatients with CD by radioimmunoassay. Age- and sex-matched controls with and without Helicobacter pylori (H pylori) infection (28 for each) were enrolled in the study. Circulating levels of these hormones were assessed with respect to CD activity, disease localization and medical treatment. RESULTS: There were no significant differences in ghrelin levels between CD patients and H pylori -negative controls. However, circulating ghrelin levels were significantly lower in H pylori-infected subjects than in CD patients and uninfected controls. Plasma leptin levels were comparable among the groups. Localization and medication profile had no significant impact on circulating ghrelin and leptin levels. CONCLUSION: Apart from H pylori infection, CD itself has no significant influence on circulating ghrelin and leptin levels in the outpatients who were mostly in inactive state. |
| Keywords: | Crohn's disease Ghrelin Leptin Helicobacter pylori |
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