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血管性痴呆的中医实验研究近况
引用本文:封银曼,龙旭阳,郑攀. 血管性痴呆的中医实验研究近况[J]. 河南中医学院学报, 2004, 19(1): 77-79
作者姓名:封银曼  龙旭阳  郑攀
作者单位:河南中医学院(封银曼,龙旭阳),河南中医学院(郑攀)
基金项目:河南省杰出青年基金资助项目 (0 112 0 0 130 0 )
摘    要:
血管性痴呆(Vascular Dementia,简称VD)的中医实验研究模型主要有4血管阻断法、颈内动脉注射微小栓子法、插线法、大脑中动脉闭塞法、双侧颈总动脉结扎法、双侧颈总动脉缺血再灌注颈总动脉反复夹闭并降血压法、高脂血症大鼠反复脑缺血再灌注法等;研究观察指标主要集中在中医药对VD模型大、小鼠的行为学,皮质、海马区组织形态学,脑血流量、脑内物质代谢的影响等领域。

关 键 词:血管性痴呆  实验研究  动物模型
文章编号:1672-6839(2004)01-0077-03
修稿时间:2003-11-02

Recent Progress in TCM Experimental Research of VD (vascular dementia)
Feng Yinman,Long Xuyang,Zheng PanHenan TCM College. Recent Progress in TCM Experimental Research of VD (vascular dementia)[J]. Journal of Henan University of Chinese Medicine, 2004, 19(1): 77-79
Authors:Feng Yinman  Long Xuyang  Zheng PanHenan TCM College
Abstract:
The research models of Vascular Dementia(VD) in TCM are made mainly by the following methods: blocking the 4 blood vessels, injecting tiny emboli to carotids, inserting cord into blood vessels, blocking the middle cerebral artery, ligating bilateral carotids, refilling bilateral carotids in the state of ischemia, repeatedly squeezing common carotid artery plus hypotensing and refilling rats with hyperlipemia and repeated cerebral ischemia. The observation is focused on the effect of TCM on behavior, cortex, histomorphology in hippocampus area, cerebral blood flow and intracerebral substance metabolism of the VD models of mice and rats.
Keywords:vascular dementia  experimental research  animal models
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