| 重组人促红细胞生成素对降低老年股骨粗隆间骨折围手术期输血的病例对照研究 |
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| 引用本文： | 解冰,田竞,杨超,周大鹏,项良碧.重组人促红细胞生成素对降低老年股骨粗隆间骨折围手术期输血的病例对照研究[J].中国骨伤,2015,28(7):633-637. |
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| 作者姓名： | 解冰 田竞 杨超 周大鹏 项良碧 |
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| 作者单位： | 沈阳军区总医院骨科,辽宁沈阳,110016 |
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| 摘 要： | 目的:评价术前应用重组人促红细胞生成素(recombinant human erythropoietin,rHuEPO)对降低老年股骨粗隆间骨折择期手术患者围手术期输血的作用.方法:回顾性分析自2011年1月至2013年12月收治的老年股骨粗隆间骨折患者442例,根据纳入及排除标准,最终入选119例.其中治疗组52例,男12例,女40例,平均年龄(71.4±12.8)岁,术前接受rHuEPO 10 000 U(隔日1次)加右旋糖酐铁200 mg(每日3次);对照组67例,男16例,女51例,平均年龄(70.9±16.2)岁,术前仅接受右旋糖酐铁200 mg(每日3次).所有患者采用PFNA-Ⅱ(辛迪思公司)或Intertan(施乐辉公司)在闭合复位下固定骨折,观察两组患者围手术期输血率、平均输血量、术后并发症、住院时间及30 d内死亡率.结果:119例中71例围手术期接受了至少1U(200 ml)异体血输入.治疗组围手术期输血率48.1％,低于对照组的68.7％(x2=4.77,P＜0.05);治疗组平均输血量(1.8±0.4) U/pte,低于对照组的(3.6±1.1) U/pte (t=2.244,P＜0.05).治疗组术后1周及30 d血红蛋白水平高于对照组,且治疗组术后30d较入院时血红蛋白水平高.两组术后血栓事件、术后感染发生率及住院时间比较差异无统计学意义.结论:对于择期手术的老年股骨粗隆间骨折患者,术前应用rHuE-PO可降低围手术期输血率及平均输血量,但其长期安全性仍有待评价.
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| 关 键 词： | 重组人促红细胞生成素 输血 老年人 髋骨折 |
| 收稿时间： | 2014/11/13 0:00:00 |
Case-control study on the efficacy of preoperative recombinant human erythropoietin administration for reducing transfusion requirements in elderly patients undergoing elective surgery for femoral intertrochanteric fractures |
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| XIE Bing,TIAN Jing,YANG Chao,ZHOU Da-peng and XIANG Liang-bi.Case-control study on the efficacy of preoperative recombinant human erythropoietin administration for reducing transfusion requirements in elderly patients undergoing elective surgery for femoral intertrochanteric fractures[J].China Journal of Orthopaedics and Traumatology,2015,28(7):633-637. |
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| Authors: | XIE Bing TIAN Jing YANG Chao ZHOU Da-peng and XIANG Liang-bi |
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| Institution: | Department of Orthopaedics, Shenyang Military Region General Hospital, Shenyang 110016, Liaoning, China;Department of Orthopaedics, Shenyang Military Region General Hospital, Shenyang 110016, Liaoning, China;Department of Orthopaedics, Shenyang Military Region General Hospital, Shenyang 110016, Liaoning, China;Department of Orthopaedics, Shenyang Military Region General Hospital, Shenyang 110016, Liaoning, China;Department of Orthopaedics, Shenyang Military Region General Hospital, Shenyang 110016, Liaoning, China |
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| Abstract: | |
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| Keywords: | Recombinant human erythropoietin Blood transfusion Aged Hip fractures |
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