芳香化酶P450在子宫内膜异位症中的表达及意义

目的：探讨芳香化酶P450在子宫内膜异位症发病中的作用。其阳性表达用于诊断子宫内膜异位症可行性。方法：应用免疫组化方法检测正常子宫内膜和子宫内膜异位症的在位及异位内膜芳香化酶P450的表达。结果：芳香化酶P450在正常子宫内膜无表达或弱阳性，在子宫内膜异位症的在位和异位内膜均有强表达，且增殖期高于分泌期表达，敏感度为92％，特异度为95．5％。结论：子宫内膜芳香化酶分泌增加促进子宫内膜异位症的发生，并对其诊断有重要意义。

The expresssion of aromatase cytochrom P450 in endometriosis and its clinical significance

Objective To study the role of aromatase cytochrom P450 in the pathogenesis of endometriosis and the practicability of it serving as a diagnostic marker for endometriosis.Methods The expression of aromatase cytochrom P450 in normal,eutopic and ectopic endometrium of endometriosis was determined by immunohistochemical assay.Results Aromatase cytochrome P450 was negative or weakly expressed in normal endometrium,but in both eutopic and ectopic endometrium of endometriosis it was highly expressed,with 92% sensitivity and 95 5% specificity.The expression of aromatase cytochrome P450 was higher in proliferative phase than in secretory phase.Conclusions The increased expression of aromatase cytochrom P450 in endometrium may play an important role in pathogenesis of endometriosis and can be used as a marker for diagnosis.