进展期肝癌患者氩氦刀冷冻消融术前中性粒细胞/淋巴细胞比值与术后预后关系研究

目的探讨氩氦刀术前中性粒细胞/淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)与进展期肝癌患者术后生存期的关系。方法回顾性分析2008—2009年在我院行氩氦刀冷冻消融治疗的150例进展期肝癌患者临床资料,根据术前NLR中位数(2.94)将患者分为2组(高NLR组和低NLR组),对2组进行生存分析和Cox回归分析。结果氩氦刀冷冻消融术前病理组织分化程度、NLR和肝硬化Child-Pugh分级是术后进展期肝癌患者生存期的影响因素。术前高NLR组患者生存期为5个月(95%CI 3.5~6.4),而低NLR组患者生存期为9个月(95%CI 6.9~11.0),2组生存期差异有统计学意义。结论 NLR2.94的进展期肝癌患者行氩氦刀冷冻消融治疗预后较差。

Association between neutrophil/lymphocyte ratio before argon-helium cryoablation and the prognosis of patients with advanced liver cancer

Objective To investigate the association between neutrophil/lymphocyte ratio (NLR) before argon-helium cryoabla-tion and the prognosis of advanced liver cancer. Methods Clinical data of 150 patients with advanced liver cancer, who underwent ar-gon-helium cryoablation in our hospital between 2008-2009, were retrospectively analyzed. The patients were divided into 2 groups (high NLR group and low NLR group) according to the median of NLR (2.94) before argon-helium cryoablation. Survival analysis and Cox regression analysis of the 2 groups were conducted. Results Pathology, the NLR before argon-helium cryoablation and Child-Pugh grade were independent risk factors for the survival of patients with advanced liver cancer. The survival of high NLR group was 5 months (95%CI 3.5-6.4), while the survival of low NLR group was 9 months (95%CI 6.9-11.0). The difference between the 2 groups was significant. Conclusion The prognosis of patients with advanced liver cancer who have a NLR of greater than 2.94 before argon-heli-um cryoablation is poor.