Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4 |
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Authors: | María Belén Acevedo J. Christopher Eagon Bruce D. Bartholow Samuel Klein Kathleen K. Bucholz Marta Yanina Pepino |
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Affiliation: | 1. Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois;2. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri;3. Department of Psychological Sciences, University of Missouri, Columbia, Missouri;4. Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, University School of Medicine, St. Louis, Missouri;5. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri;6. Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois |
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Abstract: |
BackgroundWhile it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC.ObjectivesThe aims of this study were to evaluate (1) the effect of SG, relative to RYGB and a presurgery group, on alcohol pharmacokinetics and subjective effects, and (2) whether breathalyzers are reliable in this population.SettingSingle-center prospective nonrandomized trial.MethodsWe performed alcohol challenge tests in 11 women who had SG surgery 1.9 ± .1 years ago (body mass index = 35.1 ± 6.6 kg/m2), 8 women who had RYGB surgery 2.2 ± .4 years ago (body mass index = 30.0 ± 5.2 kg/m2), and 9 women who were scheduled for bariatric surgery (body mass index = 44.1 ± 4.0 kg/m2). BACs were estimated from breath samples and measured by gas chromatography at various times after consuming approximately 2 standard drinks.ResultsBAC increased faster, peak BAC was approximately 2-fold higher, and feelings of drunkenness were heightened in both SG and RYGB groups relative to the presurgery group (P values<.001). BAC estimated from breath samples underestimated BAC by 27% (standard deviation = 13%) and missed peak BACs postsurgery.ConclusionsSG, similar to RYGB, causes marked alterations in the response to alcohol ingestion manifested by a faster and higher peak BAC. The breathalyzer is invalid to assess effects of gastric surgeries on pharmacokinetics of ingested alcohol. |
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Keywords: | Sleeve gastrectomy Bariatric surgery Metabolic surgery Pharmacokinetics Ethanol Alcohol Breathalyzer |
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