lncRNA作为ceRNA在卵巢癌中的研究进展

人类基因组中大部分为非编码区,转录产生非编码RNA(non-coding RNA,ncRNA)。ncRNA虽然不能翻译成蛋白,但可通过对mRNA直接或间接地调控影响人体生理、病理过程。长链非编码RNA(long non-coding RNA,lncRNA)是ncRNA的重要分类,越来越多的研究表明lncRNA参与癌细胞增殖、迁移、侵袭、凋亡和耐药等,影响肿瘤的发生和发展,lncRNA可作为肿瘤早期诊断、治疗和判断预后的潜在靶向标记物。竞争性内源RNA(competitive endogenous RNA,ceRNA)假说的提出使人们对肿瘤发生机制有了进一步的了解。在ceRNA的形成中,lncRNA有着重要作用。近年lncRNA作为ceRNA在卵巢癌中的研究日益增多。本文就lncRNA形成的ceRNA网络在卵巢癌的发生发展过程中的研究进展进行综述。

lncRNAs as Members of ceRNA Network and Ovarian Cancer

Most parts of the human genome are non-coding regions which produce non-coding RNA (ncRNA). Although ncRNAs cannot be translated into protein, it can affect human physiological and pathological processes through direct and indirect regulation of mRNA. Long non-coding RNA (lncRNA) is important branch of ncRNAs. LncRNA is involved in cancer cell proliferation, migration, invasion, apoptosis and drug resistance, etc. Therefore, lncRNA could be used as a marker of early diagnosis and prognosis, and therapeutic target of tumors. The hypothesis of the competitive endogenous RNAs (ceRNA) network has led to a further understanding of the mechanism of tumorigenesis. LncRNA is indispensable in the formation of the ceRNA network. In recent years, there have been more and more research on the lncRNA in ovarian cancer (OC). In this paper, we review the advance of lncRNA as a member of ceRNA network in the pathogenesis of OC.