Rh阴性孕妇妊娠结局的Meta分析

目的:分析Rh阴性孕妇的妊娠结局。方法:计算机检索中国知网、维普、万方、PubMed和Embase数据库,搜集有关Rh阴性孕妇妊娠结局的相关研究,检索时间均为1980年1月1日—2018年1月30日。由2名研究者按照纳入与排除标准筛选文献、提取资料和评价纳入研究的质量,采用RevMan 5.3软件进行Meta分析。结果:共纳入9篇文献,共4 122例研究对象,其中Rh阴性孕妇组679例,Rh阳性孕妇组3 443例。Meta分析结果显示,Rh阴性孕妇组新生儿高胆红素血症(RR=6.29,95%CI:3.64～10.85,P<0.000 01)和早产(RR=3.05,95%CI:1.80～5.15,P<0.000 1)的发生率均高于Rh阳性孕妇组。结论:Rh阴性孕妇发生新生儿高胆红素血症和早产的风险较高。因此,对Rh阴性孕妇要加强孕期监护,定期监测Rh抗体,以降低围生儿的各种并发症。

A Meta-Analysis of Pregnancy Outcomes in Rh-Negative Pregnant Women

Objective：To evaluate the pregnancy outcomes in Rh-negative pregnant women. Methods：We searched the CNKI, VIP, WanFang database, PubMed and Embase databases for the studies about the pregnancy outcomes in Rh-negative pregnant women by computers. Dated from January 1st 1980 to 30th January, 2018. Two reviewers independently screened research paper according to the inclusion and exclusion criteria, extracted data and assessed the risk bias of included studies. Then meta-analysis was performed using RevMan 5.3 software. Results：Only 9 studies with total of 4 122 cases (679 cases were Rh-negative pregnant women and 3 443 were Rh-positive pregnant women)were included in the Meta-analysis. The results of meta-analysis showed that, the incidence of newborn hemolytic disease (RR=6.29, 95%CI: 3.64-10.85, P＜0.000 01) and premature birth (RR=3.05, 95%CI: 1.80-5.15, P＜0.000 1) in Rh-negative pregnant women are higher than Rh-positive pregnant women. Conclusions：Rh-negative pregnant women were prone to neonatal newborn hemolytic disease and premature birth. Therefore, Rh-negative pregnant women and the Rh antibody should be monitored during pregnancy regularly, in order to reduce perinatal complications.