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| 磁性白蛋白纳米微粒的制备及其物理性能分析 | |
| 引用本文： | 于耀宇,李建,李立宏,曲友直,于嘉,邓建平,高国栋,张文彬,焦德让. 磁性白蛋白纳米微粒的制备及其物理性能分析[J]. 中国临床神经外科杂志, 2011, 16(10): 609-611. DOI: 10.3969/j.issn.1009-153X.2011.10.011 |
| 作者姓名： | 于耀宇 李建 李立宏 曲友直 于嘉 邓建平 高国栋 张文彬 焦德让 |
| 作者单位： | 1. 第四军医大学唐都医院神经外科,西安,710038 2. 中国人民武装警察部队医学院附属医院神经外科,天津,300162 |
| 基金项目： | 国家自然科学基金，天津市自然科学基金 |
| 摘 要： | 目的探讨磁性白蛋白纳米微粒(MAN)的制备方法及其物理性能。方法用热处理法将人血白蛋白分散在纳米磁性微粒(Fe3O4)中,并加入表面活性剂——聚丙烯酸,在超声激烈搅拌下加热,使人血白蛋白稳定,得到人浆白蛋白包裹的生物相容MAN。结果实验制备出MAN具有纳米级的大小、尺寸和形状,扫描电镜和粒径测试仪测试MAN直径为100~1000nm,且具有确切的磁响应性、磁特性、靶向性和分散性等性能。结论用热处理法可以制备出纳米级具有磁响应性、磁特性、靶向性和分散性的生物相容的MAN。 |
| 关 键 词： | 磁性白蛋白纳米微粒 制备 方法 物理性能 |
Preparation of magnetic albumin nanoparticles and analysis of their physical property |
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| YU Yao-yu,LI Jian,LI Li-hong,QU You-zhi,YU Jia,DENG Jian-ping,GAO Guo-dong,ZHANG Wen-bin,JIAO De-rang. Preparation of magnetic albumin nanoparticles and analysis of their physical property[J]. Chinese Journal of Clinical Neurosurgery, 2011, 16(10): 609-611. DOI: 10.3969/j.issn.1009-153X.2011.10.011 | |
| Authors: | YU Yao-yu LI Jian LI Li-hong QU You-zhi YU Jia DENG Jian-ping GAO Guo-dong ZHANG Wen-bin JIAO De-rang |
| Affiliation: | . ＊Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China |
| Abstract: | Objective To explore the method to prepare the magnetic albumin nanoparticles (MANs) and their physical property. Method The magnetic nanoparticles (Fe 3 O 4 ) were made by putting surface active agent, polyacrylic acid in the mixed solution of FeCl 3 and FeCl 2 , centrifugalition and drying. The human plasma albumin was dispersedin the magnetic nanoparticles and covered the magnetic nanoparticles by the heat treatment and stir with ultrasound in order to prepare biocompatible MANs. The physical property of... |
| Keywords: | Magnetic albumin nanoparticles Preparation Method Physical property |
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