GSTP1在唾液腺腺样囊性癌中的表达及意义

目的:研究谷胱甘肽S-转移酶P1(glutathione S-transferase P1,GSTP1)在唾液腺腺样囊性癌(salivary adenoidcystic carcinoma,SACC)中的表达,探讨其与SACC的临床病理特征及肿瘤发生的关系。方法:采用免疫组化法检测51例SACC和18例瘤旁腺体中GSTP1的蛋白表达,分析GSTP1表达与SACC临床病理特征之间的关系。采用SPSS13.0软件包对数据进行统计学分析。结果:GSTP1在SACC肿瘤组织中的表达显著高于瘤旁腺体(P<0.05)。在SACC肿瘤组织中,GSTP1表达的高低与组织学分级显著相关(P<0.05),在组织学3级中的表达高于1、2级。在组织学1级中,GSTP1主要在胞核表达,但随着组织学分级的升高,GSTP1在胞质中表达显著增加(P=0.022)。结论:GSTP1的高表达及在肿瘤细胞不同部位表达与SACC的发生、肿瘤细胞分化相关。

Expression of GSTP1 and its significances in salivary adenoid cystic carcinoma

PURPOSE： To study the expression of glutathione S-transferase P1（GSTP1） in salivary adenoid cystic carcinoma and discuss its relationship with clinicopathological features and tumorigenesis of SACC.METHODS： The expression of GSTP1 in 51cases of salivary adenoid cystic carcinoma and 18 samples of adjacent salivary gland tissues was detected by immunohistochemical staining method,correlation between GSTP1 expression and the clinicopathological features in SACC was analyzed.SPSS 13.0 software package was used for statistical analysis.RESULTS： The expression of GSTP1 in SACC was significantly higher than that in adjacent salivary gland tissues（P0.05）.In SACC,the strength of GSTP1 expression was significantly related to histological grade（P0.05）.The GSTP1 expression was greatly reduced in grade 1 and grade 2 tumors compared to that in grade 3.GSTP1 was mainly expressed in the nucleus in grade 1 tumors while the expression in the cytoplasm of the cells increased significantly（P=0.022） with the increase of the histological grade.CONCLUSION： Overexpression of GSTP1 and its different localizations within the cells were related to the tumorigenesis,and tumor cell differentiation of salivary adenoid cystic carcinoma.