Striatal dopamine uptake in the rat: in vivo analysis by fast cyclic voltammetry |
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| Authors: | J A Stamford Z L Kruk J Millar R M Wightman |
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| Affiliation: | 1. Department of Pharmacology, The London Hospital Medical College, Turner St., London E1 2AD U.K.;2. Department of Physiology, The London Hospital Medical College, Turner St., London E1 2AD U.K.;3. Dept. of Chemistry, Indiana University, Bloomington, IN 47405 U.S.A. |
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| Abstract: | Electrical stimulation of the median forebrain bundle of the chloral hydrate anaesthetised rat evoked dopamine release in the ipsilateral striatum, which was monitored with fast cyclic voltammetry. On cessation of stimulation, the extracellular concentration of dopamine fell to sub-detectable levels over a period of about 15 s. This fall appeared to be due to a saturable, low affinity uptake system that could be inhibited by nomifensine (20 mg/kg i.p.). These experiments constitute the first characterisation of a dopamine uptake mechanism obtained in the intact animal. |
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| Keywords: | dopamine uptake voltammetry nomifensine electrical stimulation striatum rat |
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