| 美沙酮联合曲唑酮治疗海洛因依赖的临床研究 |
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| 引用本文： | 周平良,郭中孟,龚发金.美沙酮联合曲唑酮治疗海洛因依赖的临床研究[J].中国药物滥用防治杂志,2004,10(2):72-74. |
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| 作者姓名： | 周平良 郭中孟 龚发金 |
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| 作者单位： | 江西省精神病院,南昌,330029 |
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| 摘 要： | 目的:观察美沙酮联合曲唑酮对海洛因依赖患者脱毒治疗的疗效及副反应.方法:海洛因依赖患者137例,随机分为两组:研究组(美沙酮联合曲唑酮)65例和对照组(单用美沙酮)72例.采用戒断症状评定量表、汉密顿焦虑评定量表(HAMA)和汉密顿抑郁量表(HAMD)评定患者的戒断反应、焦虑症状及睡眠障碍.结果:研究组在戒断反应、焦虑及睡眠障碍与对照组相比较,差异均有显著性(P＜0.05,或P＜0.01).两组副反应差异无显著性(P＞0.05).结论:美沙酮合并曲唑酮用于海洛因依赖者的脱毒治疗的疗效满意,副反应较少.
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| 关 键 词： | 海洛因依赖 戒断反应 曲唑酮 美沙酮 |
A Compared Study on Methadone Combined with Trazodone in the Treatment of Heroin Dependence |
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| Zhou Pingliang,Guo Zhongmeng,Gong Fajin.A Compared Study on Methadone Combined with Trazodone in the Treatment of Heroin Dependence[J].Chinese Magazine of Drug Abuse Prevention and Treatment,2004,10(2):72-74. |
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| Authors: | Zhou Pingliang Guo Zhongmeng Gong Fajin |
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| Abstract: | Objective:To observe the efficacy and side effects of methadone combined with trazodone in the treatment of heroin dependence. Methods: According to randomized design, 137 heroin addicts were divided into two groups:one group of 65 patients treated with methadone combined with trazodone, the other one of 72 patients treated with methadone alone. Results:There were significant differences between two groups in withdrawal syndrome, anxiety and insomnia (P<0.05 or P<0.01), but no difference in side effects between two groups (P>0.05). Conclusion:Methadone combined with trazodone is effective and safe in the treatment of heroin dependence. |
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| Keywords: | Heroin dependence Withdrawal syndrome Trazodone Methadone |
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