多发性硬化患者糖皮质激素受体含量与疗效的关系

目的探讨多发性硬化(MS)患者外周血白细胞糖皮质激素受体(GR)含量与糖皮质激素的治疗效果关系。方法用放射免疫法和放射配体结合法测定25例MS患者的血浆皮质醇(F)含量和血白细胞GR含量。结果MS患者血浆F含量与正常对照组无明显差异，而血GR含量为(8635±1432)位点/细胞，明显高于正常对照组(5320±540)位点/细胞(P<0.01)。用常规大剂量激素治疗时，治疗前GR位点数高者［(9356±645)位点/细胞共18例］，疗效优于位点数低者［(6176±385)7例］。结论MS患者外周血白细胞GR增多，GR含量高者近期疗效较好，GR含量低者可加用超大剂量激素治疗，以提高疗效。

A study of the relationship between of the contents of glucocorticoid receptors in multiple sclerosis patients and the efficacy of steroid therapy

Objective To explore the relationship between the contents ofglucocorticoid receptors(GR) in multiple sclerosis(MS) patients and the efficacy of steroid therapy.Methods Radio-immunological method and radioligand combination were used to determine the contents of plasma cortisol(F) and the GR contents of blood corpuscles of 25 MS cases. Results No obvious difference was found between the F contents of plasma between the group of patients and the normal control group of normal subjects whereas the GR contents in the blood of the former with (8635±1432) sites/cell were significantly higher than those of the control group with (5320±540) sites/cell(P<0.01).18 patients with high-figure GR (9356±645) sites/cell prior to treatment showed better therapeutic effects than the 7 patients with low-figure GR (6176±385) sites/cell. Conclusions Better therapeutic effects can be achieved in cases of increased blood corpuscle GR of external factors and high GR contents.Those of low GR contents may be given hormotherapy with larger doses to enhance results.