被动吸烟与肺癌的病例—对照研究

我们针对确定被动吸烟与肺癌关系设计了以医院人群为基础的病例对照研究.应用Mantel Haenssel方法及条件Logistic回归方法进行了单因素及多因素分析.结果表明:在研究对象家中有人吸烟、有1人吸烟、有2人吸烟,均发现与肺癌有显著意义的关联,OR值和95%CI分别为2.30,1.042～4.073、2.28,1.206～4.117、2.52,1.20～5.288;研究对象家中有1人在其出生前吸烟、其OR值为1.82,95%CI1.088～3.055,父亲吸烟及父亲在研究对象出生前吸烟其OR值与95%CI分别为2.13,1.179～3.858、2.28,1.275～4.061,同时我们还发现与吸烟的配偶生活20年以上者患肺癌的危险增加,OR值和95%CI为2.17,1.203～3.914;做饭年限超过25年,厨房与卧室相通者与肺癌间存在显著意义的关联.OR和95%CI分别为2.06,1.042～4.073、2.78,1.137～6.791.本研究未发现有统计学上显著意义的交互作用.有关母亲吸烟,服用维生素C,维生A,肺癌家族史及经济水平等因素均未发现在统计学上有显著意义的关联.

A Case-Control Study of Passive Smoking and Lung Cancer

In 1989, we conducted a case-control study on relation letween passive smoking and simcidence lung cancer in seven cities, China. 132 were collected,at same time,264 controls were collected from the same hospital with casses matched in respect to sex,age( / - 2),and hospitalizing date. The TEPUNFO and PECAN procedure were used to calculate the crude odds ratio and adjusted odds ratio respectively. Our results showed that the factors for one or more than one person smoking in the family more than one person smoking before the birth of subject,statistically significantly associate with lung cancer,the OR and 95% Cl are2. 28,1.206 - 4.117,2. 52,1.20-5.288 and 1.82,1.088 -3. 055 respectively; Factors for father' s smoking and smoking before birth of subjects,over 20 years living with smoking father could increase the risk or contracting lung cancer, the OR and 95% Cl are 2.13,1-179-3.858,2.28,1.275-4.061,2. 01,1.037 - 3.877 respectively t Also the statistically significantl association with present lung cancer are found in cooking over 25 years and having the history of chronic bronchitis, the oR and 95% CI are 2.06, 1.042- 4.073, 2.78, 1.137-6.791. There are no significant associations existed in the factors as mother' s smoking,economic status and an interactions.