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Epidural pethidine and bupivacaine in labour
Authors:N. D. Edwards  MB  BS  FRCAnaes M. Hartley  MB   P. Clyburn  MB  BS  FRCAnaes M. Harmer  MB  BS  FRCAnaes
Affiliation:University Hospital of Wales, Heath Park, Cardiff.
Abstract:
A double-blind randomised study was performed to assess the value of the addition of pethidine 50 mg to the initial dose of bupivacaine given for epidural analgesia in labour. Forty-nine patients received either 1 ml of saline (n = 24), or 50 mg of pethidine (n = 25), added to 9 ml of 0.25% bupivacaine as an initial injection for intrapartum epidural analgesia. There was a significant increase in the mean duration of analgesia in the pethidine group. However, pethidine did not increase the speed of onset of analgesia, or improve the quality of analgesia.
Keywords:Analgesics    pethidine    Anaesthesia    obstetric    epidural    Anaesthetic agents    local    bupivacaine
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