首页 | 本学科首页   官方微博 | 高级检索  
     

红果槲寄生抗肿瘤有效部位的确定
引用本文:凌勇,孙永慧,赵芹,刘洪玲,于良生,孙向红. 红果槲寄生抗肿瘤有效部位的确定[J]. 中国实验方剂学杂志, 2011, 17(10): 193-195
作者姓名:凌勇  孙永慧  赵芹  刘洪玲  于良生  孙向红
作者单位:1. 青岛大学医学院附属医院,山东青岛,266003
2. 黑龙江中医药大学,哈尔滨,150040
摘    要:目的:确定红果槲寄生[Viscum coloratum(Kom.)Nakai f.Rubroaurantiacum Kitag,VCR]的抗肿瘤有效部位。方法:以S180实体瘤小鼠作为动物模型,以抑瘤率为考察指标,对红果槲寄生75%乙醇提取物的不同溶剂萃取部位:石油醚萃取部分、氯仿萃取部分、乙酸乙酯萃取部分、正丁醇萃取部分以及水层部分分别进行了抗肿瘤活性筛选。将接种肿瘤的昆明小鼠在成瘤后按照瘤体大小随机分为7组,阳性对照组于ip环磷酰胺,给药剂量为100 mg·kg-1,其他试验组于同一时间ig给药,每天1次,给药剂量按生药量计为14.2 g·kg-1,空白对照组给予相同剂量的空白溶剂,连续给药8 d。结果:红果槲寄生提取物能明显抑制小鼠S180实体瘤生长,其中正丁醇萃取物组,平均抑瘤率为48.8%;氯仿萃取物组,平均抑瘤率为44.1%。结论:正丁醇和氯仿萃取部分抗肿瘤活性较强,为红果槲寄生抗肿瘤有效部位。

关 键 词:红果槲寄生  抗肿瘤  有效部位
收稿时间:2010-11-24

Determination of Effective Part of Anti-tumor Activity in Viscum coloratum (Kom.)Nakai f. Rubroaurantiacum Kitag
LING Yong,SUN Yong-hui,ZHAO Qin,LIU Hong-ling,YU Liang-sheng and SUN Xiang-hong. Determination of Effective Part of Anti-tumor Activity in Viscum coloratum (Kom.)Nakai f. Rubroaurantiacum Kitag[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(10): 193-195
Authors:LING Yong  SUN Yong-hui  ZHAO Qin  LIU Hong-ling  YU Liang-sheng  SUN Xiang-hong
Affiliation:Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China;Heilongjiang University of Chinese Medicine, Haerbin 150040, China;Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China;Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China;Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China;Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China
Abstract:Objective: ascertain the effective part of anti-tumor activity in Viscum coloratum (Kom.)Nakai f. Rubroaurantiacum Kitag(VCR). Method :We made sarcoma S180 mice as the animal model, the inhibition rate of tumor was used as investigation index. We carried out the screen assay of the anti-tumor for different solvent extraction part of the VCR extracts by 75% alcohol,including petroleum extraction part,chloroform extraction part,acetate extraction part,n-butanol extraction part and the rest. We randomly divided mice with inoculated tumor into 7 groups according to tumor size. The positive control group of mice were given ip cyclophosphamide of 100 mg ·kg-1,the other experimental group at the same time were given ig of 14.2 g ·kg-1 ·d-1 and the blank control group were given the same volume of the blank solvent,continuously administrated for 8 days. Result: The results showed that the extraction of VCR could obviously prevent the growing of the tumor in mice. The inhibition rate of tumor for the chloroform extraction part was 48.8%;the rate of the n-butanol extraction part was 44.1%. Conclusion: The chloroform extraction part and the n-butanol extraction part are the effective part of anti-tumor from VCR.
Keywords:Viscum coloratum (Kom.)Nakai f. Rubroaurantiacum Kitag  anti-tumor activity  effective part
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《中国实验方剂学杂志》浏览原始摘要信息
点击此处可从《中国实验方剂学杂志》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号