Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder |
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| Authors: | Marijn Lijffijt J. Leon Kenemans Annemiek ter Wal Elise H. Quik C. Kemner Herman Westenberg Marinus N. Verbaten Herman van Engeland |
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| Affiliation: | Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. malijffi@utmb.edu |
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| Abstract: | PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention. SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design. RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively. DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles. |
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| Keywords: | Attention-deficit/hyperactivity disorder Methylphenidate Stop-signal paradigm Inhibitory control Attention Blood serum |
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