| 自身免疫性甲状腺病患者外周血T淋巴细胞CTLA-4和CD40L的表达 |
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| 引用本文： | 王宇,张健,张进安,肖婉侠,全瑛,刘琳,王荣.自身免疫性甲状腺病患者外周血T淋巴细胞CTLA-4和CD40L的表达[J].第四军医大学学报,2009(18). |
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| 作者姓名： | 王宇 张健 张进安 肖婉侠 全瑛 刘琳 王荣 |
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| 作者单位： | 西安交通大学医学院第一附属医院内分泌科;西安市第一医院;西安交通大学医学院第一附属医院检验科; |
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| 基金项目： | 国家自然科学基金(30871185); 陕西省科技攻关项目(2007k12-02) |
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| 摘 要： | 目的:通过检测自身免疫性甲状腺病(AITD)患者外周血T淋巴细胞表面细胞毒性T淋巴细胞相关抗原-4(CTLA-4,CD152)和CD40配体(CD40L,CD154)的表达,阐明共刺激分子在自身免疫性甲状腺病发生中的作用.方法:对30例Graves病(GD),20例桥本甲状腺炎(HT)患者和20例健康对照者采用流式细胞仪分析了共刺激分子在外周血T淋巴细胞上的表达.结果:与正常对照相比,外周血T淋巴细胞表达CTLA-4的百分数在GD患者中升高,在HT患者中降低.GD患者表达CTLA-4百分数与TSAb滴度呈正相关.结论:AITD外周血T淋巴细胞呈现共刺激分子的异常表达,某些分子的表达与自身抗体水平有相关性,提示共刺激分子参与了AITD的免疫发病机制.
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| 关 键 词： | 自身免疫 甲状腺病 T淋巴细胞 CTLA-4 CD40L |
Expression of CTLA-4 and CD40L on periperal T lymphocytes in autoimmune thyroid disease |
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| WANG Yu,ZHANG Jian,ZHANG Jin-An,XIAO Wan-Xia,QUAN Yin,LIU Lin,WANG Rong.Expression of CTLA-4 and CD40L on periperal T lymphocytes in autoimmune thyroid disease[J].Journal of the Fourth Military Medical University,2009(18). |
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| Authors: | WANG Yu ZHANG Jian ZHANG Jin-An XIAO Wan-Xia QUAN Yin LIU Lin WANG Rong |
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| Institution: | WANG Yu,ZHANG Jian,ZHANG Jin-An1,XIAO Wan-Xia1,QUAN Yin1,LIU Lin1,WANG Rong11Department of Endocrinology,2Department of Clinical Medicine,First Affiliated Hospital,Medical College,Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | AIM: To investigate the possible abnormal expression of costimulatory molecules of cytotoxic-T-lymphocyte-associated-antigen-4(CTLA-4,CD152) and CD40 ligand(CD40L,CD154) on peripheral blood T cells in patients with autoimmune thyroid disease(AITD) and to analyze the possible relation between these molecules and clinical indices.METHODS: The expression of costimulatory molecules on peripheral blood CD3+T lymphocytes was detected by two-color flow cytometry in 30 patients with Graves' disease(GD),20 patients ... |
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| Keywords: | autoimmune thyroid disease T lymphocyte CTLA-4 CD40L |
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